Cell Cycle Stages
How many stages are in the cell cycle?
4
True or False: CDKs need cyclins in order to function/ be active.
True
Define Protooncogene
A normal gene which, when altered by mutation, becomes an oncogene that can contribute to cancer
The first stage of the APC
1. Phosphorylation by cdk-cyclin complex
Define the cell cycle
The cell cycle is a regulated series of events that occurs to ensure cell division occurs.
What is the primary function of this complex?
Phosphorylation of substrates/proteins involved in the cell cycle
Define Tumor Supressor
The complex adds _____ to securin-separase; freeing separase
ubiquitin
Which cell cycle stage is involved in DNA synthesis
S phase
T/F Cyclins are present at specific times of the cell cycle
True
What type of mutations do proto-oncogenes undergo?
Gain of function
APC allows progression of cell cycle to what stage?
Anaphase
Which cell cycle stage is involved in growth and preparation for mitosis?
G2
What type of mutations do tumor suppressors undergo?
Loss of function