About Us
Which one of the following statements represents the MCS mission?
A. To empower every person and every organization on the planet to achieve more
B. Drive global operational innovation focusing on sample laboratory set up, ESP or internal partnership, and synergies in clinical studies
C. Enabling Proof of Biology and Precision Medicine by translating innovative approaches from bench to bed side and patient home
D. Quantify the patients response to disease and treatment by applying cutting edge analytics and machine learning methods to data generated
C. Enabling Proof of Biology and Precision Medicine by translating innovative approaches from bench to bed side and patient home
What is the mechanism of action of LNP023?
A. It complements inhibition of pathological pathways on top of standard of care
B. It is complimentary
C. It inhibits the alternative complement pathway
D. It completely does not matter, as long as it is a good alternative to standard of care
C. It inhibits the alternative complement pathway
Who discovered molecular basis of sickle cell disease, the first molecular disease?
A. Albert Einstein
B. Linus Pauling
C. James Watson
D. Sidney Brenner
B. Linus Pauling
MCS Innovation is NOT based on
A. Cutting edge technology
B. Collaborations
C. Working in isolation
D. Identifying biomarkers for heterogenous diseases
C. Working in isolation
MCS Study Lead functions as
A. The single point of contact from MCS for the study team
B. The one who runs experiments in the lab
C. The one who purchases lab items
D. Someone who cannot work from home
A. The single point of contact from MCS for the study team
What is the official molecule name for LNP023?
A. Avacopan
B. Fabacopan
C. Iptacopan
D. Kurtcoban
C. Iptacopan
Which hemoglobin does not exist in healthy adult?
A. HbA
B. HbA2
C. HbF
D. HbC
D. HbC
Tissue Biomarker Core Team members are from
A. BMD, PCS, OTR, ATI ITR and Precision medicine
B. MCS, Precision Medicine and GDC
C. CBT, ATI and OTR
D. Precision Medicine and TRD
A. BMD, PCS, OTR, ATI ITR and Precision medicine
Select all that are true: SME roles in MCS are
A. Technical / platform related SMEs
B. TA related SME to support TAH model / Portfolio
C. Program related SME / SL to support PRiME model and working closely with GDD/PM.
D. Direct point of contact from MCS
A. Technical / platform related SMEs
B. TA related SME to support TAH model / Portfolio
C. Program related SME / SL to support PRiME model and working closely with GDD/PM.
Which BMD teams were involved in the LNP023 program so far?
A. MCS
B. LEO
C. CTI
D. QSI
E. All of the above
E. All of the above
What is the mode of action of ADPT03?
A. It increases HbA expression through delivering functional copies of the beta-globin gene through lentiviral vector
B. It increases HbF expression through delivering functional copies of the gamma-globin gene through lentiviral vector
C. It increases HbF expression through genome edit by CRISPR/Cas9 approach
D. It increases HbF expression by small molecule ADPT03 compound
C. It increases HbF expression through genome edit by CRISPR/Cas9 approach
Which one of the below mentioned modality is NOT part of tissue biomarkers project
A. Proteomics
B. Metabolomics / Lipidomics
C. Foodomics
D. Transcriptomics
C. Foodomics
MCS labs are in
A. Cambridge and Basel
B. Cambridge, Basel and China
C. Basel and China
D. India, Cambridge, China and Basel
A. Cambridge and Basel
What Kidney Injury and Inflammation markers are analyzed in LNP023 in C3G patients? Select correct response
A. Urinary Clusterin, NGAL and IL-18
B. Urinary NGAL, Cystatin B and HDL
C. Urinary IL-18, NGAL and Cystatin C
D. Urinary Cystatin B, Glucose and HDL
C. Urinary IL-18, NGAL and Cystatin C
Flow cytometry can be used to detect
A. White blood cell
B. TP53 mutation
C. Erbb2 RNA expression
D. serum IL-10
A. White blood cell
Exhaled Breath Condensate is analyzed by
A. Mass Cytometry
B. Inductively Coupled Plasma- Mass Spectrometry (ICP-MS)
C. Gas-Chromatography – Mass Spectrometry
D. Imaging Mass Spectrometry
B. Inductively Coupled Plasma- Mass Spectrometry (ICP-MS)
On a study, what does the MCS Assay Specialist do?
A. Acts as the point of contact from MCS
B. Assay development and carry out sample analysis
C. Does not run any experiments
D. Does not interact with ESP
B. Assay development and carry out sample analysis
LNP023 is NOT evaluated in
A. Complement-mediated kidney diseases
B. Alzheimer’s
C. Paroxysmal nocturnal hemoglobinuria (PNH)
D. Immune Thrombocytopenia (ITP)
B. Alzheimer’s
2020 Nobel prize for CRISPR / Cas9, DNA edit was awarded to
A. Emmanuelle Charpentier and Marie-Curie
B. Emmanuelle Charpentier and Jennifer A. Doudna
C. Jennifer A. Doudna and Gertrude B Elion
D. Jennifer A. Doudna and Frances H. Arnold
B. Emmanuelle Charpentier and Jennifer A. Doudna
Biomarkers from synovial fluid shed light on
A. Atherosclerosis
B. Diabetes status
C. Endotypes in Osteoarthritis clinical population
D. Sickle cell disease
C. Endotypes in Osteoarthritis clinical population