receptors
which receptor always drops diastolic bp
what is beta 2 agonists
which receptor type is contradicted in patients with asthma (DO NOT USE!!!)
on a graph- what effect will an INDIRECT agonist have on norepinephrine
curve shifts to the left, no change in emax (indirect increase the amount of ne in the synapse- more potent)
what is the difference between the structure of epi and ne
which drug is the tachycardia champion
what is isoproterenol
what receptor is clonidine selective for
what is alpha 2 selective
what is beta blockers main clinical usage
what is to treat hypertension
where is epinephrine made
what is the adrenal medulla
substitution @ 4 position usually confers ____ selectivity
what is beta 1
which drug increase hr and decreases bp
isoproterenol (non selective beta agonist- beta 1 increase hr beta 2 decrease bp)
which receptor will cause a vagally mediated reflex bradycardia with iv admin
what is alpha 1
what is the only alpha 2 selective alpha antagonists
what is yohimbine
which amino acids can bind to the protonated amine is b2-receptor binding
what is asp or glu
what amino acid to catechol hydroxyls bind
what is ser
what is the most common adr of beta 2 agonists
what is tremor
What receptor increases renin secretion
what is beta 1
which drug increases systolic and decreases diastolic
what is epi (increase systolic beta 1- decrease diastolic beta 2)
if acute myocardial infarction was caused by ephedrine-induced increased myocardial oxygen demand what drug type might be effective in reversing this
what is beta blockers
In order for a drug to be susceptible to COMT metabolism what must its structure have?
what is a catechol ring
For a drug to act solely by an indirect mechanism the structure must have NO ____ NO ______
what is no catechol and no beta hydroxyl
which receptor decreases potassium
what is the primary mechanism of ephedrine on cardiovascular action
what is release of stored catecholamines
which drug (direct or indirect agonists) will retain its full affect if sympathetic nerve terminals have been depleted of norepinephrine?
what is direct agonists (direct agonists do not need NE in the neuron)
in a drug structure if an amine has a T-BUTYL R group it is more selective for
what is beta 2
"olol" is aryloxypropanolamines or arylethanolamines
what is aryloxypropanolamines