Chicago Fun Facts
Biology
Pop Culture
Anatomy
Geography
100

This shiny Chicago landmark’s official name refers to its appearance as a gate to the sky.

What is Cloud Gate

100

These blood cells are the body's primary defenders against infections and disease.

What are white blood cells, or leukocytes?

100

This Sabrina Carpenter hit became her first Billboard Hot 100 Top 10 song in the spring of 2024.

What is “Espresso”?

100

The human heart is divided into this many chambers: two atria and two ventricles.

What is four?

100

This iconic Chicago street is home to the Magnificent Mile and crosses the Chicago River via a massive double-leaf bridge.

What is Michigan Avenue?

200

Before being renamed in 2009, this famous Chicago skyscraper was known by the name of the department store that commissioned it.

What is the Sears Tower?

200

A permanent change in the DNA sequence of a gene is known by this term.

What is a mutation?

200

In Outer Banks, John B leads this group of working-class teenagers from the south side of the island.

Who are the Pogues?

200

This is the body's largest organ and forms the outer covering of the body.

What is skin?

200

Stretching more than 4,300 miles along the western coast of South America, this is the world's longest continental mountain range.

What are the Andes Mountains?

300

In 1982, seven people in the Chicago area died after this popular over-the-counter pain reliever was laced with potassium cyanide.

What is Tylenol?

300

A typical human body cell contains this many chromosomes. 

What is 46? (23 Pair)

300

In A Minecraft Movie, Jack Black takes on the role of this iconic blocky character.

Who is Steve?

300

This protein inside red blood cells is responsible for carrying oxygen throughout the body.

What is hemoglobin?

300

Carved by the Colorado River through Arizona, this massive canyon is one of the world's most famous natural wonders.

What is the Grand Canyon?


400

Eight Chicago-area friends launched a Kickstarter in 2011 to create this famously politically incorrect party game.

What is Cards Against Humanity?

400

Humans, apes, monkeys, and lemurs all belong to this order of mammals.

What are primates?

400

This European country won the 2010 FIFA World Cup, defeating the Netherlands in the final.

What is Spain?

400

This is both the strongest and longest bone in the human body.

What is the femur?

400

This famous artificial waterway cuts across Central America, allowing ships to travel between the Atlantic and Pacific Oceans.

What is the Panama Canal?

500

Founded in Chicago in 1901, this pharmacy chain now has more than 8,000 stores across all 50 states and acquired Duane Reade in 2010.

What is Walgreens?

500

These two diseases, are considered the most common human issues.

What are Cavities and gum disease?

500

This 1986 comedy starring Matthew Broderick is widely recognized as the most popular movie filmed in Chicago.

What is Ferris Bueller’s Day Off?

500

Unlike veins, these blood vessels carry blood away from the heart.

What are arteries?

500

North Avenue Beach sits on the shores of this Great Lake, the only Great Lake located entirely within the United States.

What is Lake Michigan?

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