Type 1
Type 2A
Type 2B
Miscellaneous
100
The 3 P's (organs involved) of MEN 1
What is:
Pituitary tumors
Pancreatic endocrine tumors
Parathyroid adenomas
100
How is MEN 2A inherited?
What is:
An autosomal dominant fashion.
100
What gene is associated with MEN-2B?
What is RET. But what is different about it in MEN-2B when compared to MEN-2A
100
MEN is an acronym for
What is Multiple Endocrine Neoplasia
200
The most common MEN 1 Pituitary Tumor secretion
What is Prolactin (70%)
Second most common is Growth Hormone
200
What are three disorders characteristic of MEN 2A?
What is:
Medullary carcinoma
pheochromocytoma,
parathyroid adenomas
200
Is the prognosis for MEN-2B better or worse than MEN-2A, and why?
What is it's worse because you develop multifocal lesions that are more aggressive
200
The inheritance pattern of MEN 1
What is Autosomal Dominant Inheritance
**Note, studies indicate it as a 2 hit hypothesis !
300
A Pancreatic endocrine tumors that causes gastric and duodenal ulcers associated with MEN 1.
What is Zollinger-Ellison Syndrome
300
What is another name for MEN 2A syndrome?
Sipple’s Syndrome
300
Most patients with MEN-2 develop what kind of lesions?
What is thyroid carcinoma and pheochromocytoma
Note that <10% of pheochromocytomas are malignant in MEN-2A
300
Hallelujah?
What is, it's raining MEN
400
Non endocrine tumors associated with MEN 1 Include
Angiofibromas (tumor of blood vessels and fibrous tissue of the face), collagenous (flesh colored tumors on the skin), and meningiomas (uncommon nervous system tumors)
400
What specific gene mutation is associated with MEN 2A? (Associated with medullary carcinoma)
What is:
A RET gene mutation
400
People with germ line RET gene mutations should do what?
What is get a Prophylactic thyroidectomy
400
Which MEN syndrome has no parathyroid involvement? (No parathyroid hyperplasia)
What is: MEN 2B
500
The Mutation Associated with MEN 1
What is:
Menin, a tumor suppressor, found on chromosome 11.
11q13 mutation
500
_______ is a pruritic, scaly, papular skin lesion, located in the interscapular region or on extensor surfaces.
What is:
Cutaneous lichen amyloidosis
500
Patients with MEN-2B have what 2 extra-endocrine manifestations?
Ganglioneuromas at mucosal sites
Marfanoid habitus - overly long bones
500
This (These) type(s) of MEN is associated with recurrent kidney stones:
What is MEN1 and MEN 2A