RTOG 0539
Dose and fractionation
54Gy in 30 fractions
Another name for grade I, grade II and grade III
Benign, atypical and malignant
Characteristic dose deposition towards the end
Bragg peak
Complete removal and coagulation of dural attachment: Simpson grade ___
Simpson grade 2
World War I began in this year
1914
Three types of radiation therapy allowed in trial
3D-CRT, IMRT and proton therapy
Year of publication for the most recent update
2016
Two radiological adverse events as a result of radiation treatment for meningioma
Radiation necrosis and white matter lesion
Laminated calcific concretions associated with meningioma
Psammoma bodies
Adolf Hitler was born in this country
Austria
Patient selection criteria
Recurrent WHO grade I or de novo WHO grade II
Frequency of grade II in meningioma
5-7%
Proton therapy, compared with photon therapy, resulted in _______ integral dose, _______ rate of radiation necrosis and _______ rate of out-of-field recurrence
Lower, higher, higher
The most common meningeal site for development of meningioma
Arachnoid granulation (villi)
John F. Kennedy was assassinated in this city
Dallas TX
3-year PFS
93.8%
Criteria for grade II, name three
≥4 mitoses/10 HPF, brain invasion or ≥3 features below:
• Hypercellularity
• Small cells w/ high nuclear:cytoplasmratio
• Prominent nucleoli
• Patternless/sheet-like growth
• Foci of spontaneous necrosis
Unit of beam energy used in proton therapy
Gy(RBE) or CGE (cobalt gray equivalent)
Peak age of incidence of meningioma (in decade)
60's
The Magna Carta was published by the King of this country
England
Three most common grade 2 adverse events
Seizure, speech disorder, olfactory nerve disorder
Meningioma pathologic subtypes, name three
Meningothelial, Fibroblastic, Transitional, Psammomatous, Angiomatous, Microcystic,
Secretory, Metaplastic, Lymphoplasmacyte-rich, Chordoid, Clear cell, Atypical, Anaplastic, Papillary, Rhabdoid
Location of proton therapy treatment centre in Canada
TRIUMF, Vancouver BC
Bony structure involved by meningioma
Clivus
Old name for New York City, coined by the first European settlers in 1624
New Amsterdam