Vit D
What is a source of Vitamin D?
Salmon, egg yolks, milk
Magnesium acts as a natural antagonist to which ion inside cells?
Calcium
What cancer is associated with folate and B12 deficiency
Colorectal Caner
What does CRC stand for?
Colorectal Cancer
What is Cisplatin?
Type of platinum-based chemotherapy
Crosslinks with purine bases on DNA
-Causes DNA damage and induces apoptosis
-Targets cells that are rapidly dividing - cancer cells
This chemotherapy drug causes hypomagnesemia in 40–90% of treated patients due to renal magnesium wasting
What is one Function of Vitamin D?
Ca absorption, immune regulation, cell maturation, hormone messenger
What's an example of a food with magnesium?
leafy green vegetables, such as spinach.
legumes.
nuts and seeds.
whole grains
What is the main function of folate?
Is a coenzyme in one-carbon metabolism.
Out of 8 women, how many are diagnosed with breast cancer?
1
Is radiation treatment used for colon or rectal cancer?
Rectal
Where is id Vitamin d converted to its active form?
Kidneys
Which area of where magnesium is stored do enzymatic reactions occur?
Intracellular (39-49%)
B12
What is the name of the tumor growths in CRC?
Polyps
What does chemotherapy do?
Its a drug that stops the growth of cancer cells via the bloodstream.
What acts as a blockade to inhibit the cell from reading the ID1 gene expression?
VDRE
Which part of the nephron tubule has the TRPM6 channels?
Distal convoluted tubule (DCT)
The conversion of homocysteine to methionine is used to produce what?
SAM
Why is pCR important? What does it stand for?
It reflects the disappearance of cancer cells in the tissue. Pathological complete response.
What is nephrotoxicity?
Magnesium supplementation during cisplatin therapy has been shown to reduce this major dose-limiting toxicity of the drug without decreasing antitumor efficacy.
What percentage of pCR did the vitamin d group have compared to the placebo group in the study?
43.2% compared to 23.7%
What is parathyroid hormone (PTH)?
High serum magnesium suppresses this hormone, reducing renal magnesium reabsorption.
What consequence of folate deficiency increases colorectal cancer risk by impairing nucleotide synthesis and DNA repair?
DNA impairment/instability
Where does the occupied VDR travel to form the blockade?
DNA
Which cells are targeted by chemoherapy treatment in colorectal cancer?
Intestinal cells