ENDOCrying
What is the pharmaceutical treatment of choice for hyperthyroidism and Grave's disease? FIRST line
Methimazole - #1 OR Propylthiouracil (antithyroid medications)
Surgery = only cure; Radioactive Iodine is an alternative treat however is relatively contraindicated in patients with exophthalmos; patients are routinely given ppx prednisone if receiving RAI + ophthalmic manifestations
Name one medication that can protect an individual against developing gall stones.
Which cancer pharm class used to treat multiple myeloma, sarcoma, breast/lung cancers, and Hodgkin's can lead to the development of Leukemia?
Alkylating Agents: Cisplatin, Triazines, Cyclophosphamide, Ifosphamide.
Minimum anticoagulation therapy during following a pulmonary embolism?
3 mos
High risk: recent cancer treatment, 2 VTE - indefinite
Status epilepticus first line?
Benzodiazepines
Propranolol to treat tachycardia or tremors
thyroiditis is self limiting
This antinausea medication can cause tissue necrosis and is Contraindicated in children <2yoa.
Promethazine (Phenergan)
Anti-estrogen drug used to tx breast cancers?
Tamoxifen
what is given in acute severe asthma exacerbations after Albuterol nebulizer/MDI, SAMA (Ipratropium), IV Methylprednisolone is given.
IV Magnesium Sulfate over 20 minutes
First line for the treatment of narcolepsy and idiopathic hypersomnia?
Modafinil
DOC: dopamine agonist usually the first line treatment for patients with hyperprolactinemia
Has the ability to shrink acromegaly-associated pituitary tumors or tumors containing prolactin or growth hormone overgrowth
Cabergoline;
What medication can be used to treat and slow the progression of Primary Sclerosing cholangitis, a slow progressing autoimmune disease of the liver.
What type of imaging is performed prior to initiating Doxirubicin?
MUGA Scan
Radiation induce lung injury and Sarcoidosis can be treated using what class of drugs?
Only drug proven to increase survival in Alzhiemer patients?
Riluzole - inhibits glutamic acid release; blocks NMDA and sodium channels
Diabetes Insipidus is most commonly due to trauma or tumor; laboratory studies usually show hypernatremia
What medication is used to treat this and what is the mechanism of action?
DDAVP; Desmopressin intranasally q8-24 hrs
can also be given IM, PO, or SQ
These medications help treat irritable bowel syndrome by blocking the action of acetylcholine at the parasympathetic sites in the secretory glands, smooth muscle, and CNS. Reduce bowel contractions
Antispasmodics
1. hyoscyamine
2. dicyclomine
Check-point inhibitor: Pembrolizumab (Keytruda) what is the MOA of Keytrude/Pembrolizumab
Passive immunotherapies: do not rely on the body to attack the disease; antibodies are created and injected to help fight the cancer
Respiratory stimulants like Theophylline can cause what adverse reactions to occur when >30g/L serum level.
Arrhythmias and Seizures
PML (progressive multifocal leukoencephalopathy) occurs when patients with MS are treated with what medication class due to the reactivation of the John Cunningham Virus?
Monoclonal antibodies
- Natalizumab
- Ocrelizumab
- Alemtuzumab
What is the maintenance therapy of Addison's Disease?
Pathophysiology: deficiency of adrenal glands
Hydrocortisone & Fludrocortisone acetate
Cimetidine, which is used as maintenance therapy in PUD, leads to what metabolic abnormality when used for 2 years or longer.
B 12 deficiency
What can be used to treat dry desquamation from radiation treatment?
DOMEBORO SOAKS, Silvadene, narcotic pain medication
First line treatment of Acute bronchitis in a NONSMOKER.
Smokers?
Azithromycin
Doxycycline - smokers
Zofran (ondansetron), commonly used as an antiemetic in cancer or post op patients, blocks what receptors?
serotonin
5-HT3