Hypersensitivity
What cell mediates anaphylactic reactions?
Mast cells
In the rheumatoid factor test, what is being detected?
IgM directed against the Fc portion of IgG
What is a haplotype?
Closely linked alleles on a single chromosome. One from each parent.
What is an epitope?
Part of immunogen that is recognized by lymphocytes.
Which isotype of immunoglobulin is involved in type I hypersensitivity?
IgE
What is the characteristic antinuclear antibody pattern produced by antibody to DNA-histone complexes?
Homogeneous
How are HLA antibodies detected in a patient?
Reagent lymphocytes are incubated with patient serum
What does HLA stand for?
Human Leukocyte Antigen
Which immune mechanism is involved in contact dermatitis?
Sensitization of cytotoxic T cells
What does a DAT test detect?
In vivo attachment of antibodies to red blood cells.
In a patient who is exhibiting signs of graft-versus-host disease, which cell type is most likely responsible for the reaction?
T cells
Which cell has the highest level of MHC I molecules?
Lymphocytes then myeloid cells
What type of therapy is achieved by gradually increasing doses of the allergen over time to induce production of blocking IgG4 antibodies?
Allergy immunotherapy
What organ does Graves disease target?
Thyroid
pig valve into a human heart
Where are Class II MHC molecules primarily found?
APCs
What type of hypersensitivity is Rheumatoid Arthritis?
III
Antibodies directed against thyroglobulin represent a significant finding in which autoimmune disease?
Hashimoto's thyroiditis
What process involves massive cytokine release, inflammation, and destruction of various tissues?
Graft-Versus Host Disease
Which classes of MHC can induce graft rejection?
I and II