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FINAL JEOPARDY
100
The study of the movement of a drug in the body is called?
Pharmacokinetics
100
How many half lives does it take to get to 87.5% drug elimination?
3
100
What type of drugs pass the BBB?
Small lipophilic
100
Vessel rish organs receive approximately what percent of cardiac output?
~75%
100
Are drugs reabsorbed from the tubules when they are in their ionized or nonionized form?
Nonionized
100
The study of a drug and its related effects is called?
Pharmacodynamics
200
Cytochromes are part of which phase of biotransformation?
Phase 1
200
Which plasma binding protein predominantly binds acidic compounds?
Albumin (it's negatively charged)
200
Which plasma binding protein predominantly binds basic compounds?
AAG (positively charged)
200
Buprenorphine requires what theoretical amount of receptor occupancy for maximal effect?
10-20% 40-60% 80-100% >100%
Partial agonist so >100%
200
Name two vessel poor compartments?
Bone, ligament, cartilage
200
Phase 2 of biotransformation is called?
Conjugation
300
Drug B is considered to be more __________.
Potent
300
Time required for 50% decrease in plasma drug concentration following a pseudo steady-state infusion.
Context sensitive half time
300
Drug A is considered to be more ________.
Efficacious
300
Name three patient factors that decrease albumin concentrations.
Kidney disease, liver disease, CHF, malignancy
300
TD50/ED50 = ?
Therapeutic index
300
Bolus dose of a drug divided by the plasma concentration at time zero equals what?
Volume of distribution
400
Which graph represents zero, first and second order kinetics respectively?
1st, 2nd, Zero
400
You are taking care of a chronic pain patient, what change will occur to the dose response curve in regards to opioids?
Right Shift
400
A patient does not have an IV, name four routes of administration that bypass first pass metabolism.
Transdermal, buccal, rectal, intranasal, transpulmonary, transmucosal, subcutaneous, intramuscular
400
Name four IV meds that can also be given via the ET tube.
Lidocaine, epinephrine, atropine, narcan, milrinone
400
Name one patient factor that decreases AAG concentration.
Pregnancy
400
This region is defined as?
Therapeutic index
500
Name five vessel rich organs.
Heart, brain, liver, kidney, endocrine
500
Which graph depicts a competitive antagonist vs noncompetitive antagonist being given?
A. 
B. 
A- noncompetitive, B- competitive
500
Which agent is most protein bound? What will be its half life compared to the other agents?
Bupivacaine - high half life, increased duration, low volume of distribution, stays within plasma volume
500
A patient is complaining of having minimal benefit from tramadol and vicodin. Which process of pharmacokinetics is the cause for this lack of efficacy?
Phase 1 of biotransformation
500
During the end of a TIVA case, you bolus ephedrine. What will this theoretically do to your emergence time and why?
Decrease
Increase CO, propofol is hepatic flow dependent so the increased flow will increase rate of metabolism
500
What process of pharmacokinetics is presented here?
Phase 2 of biotransformation
M3G = excitatory
M6G = analgesia
500
Label the related drug to the context sensitive half time.
Thiopental, Midazolam, Fentanyl, Remifentanil, Propofol
