That's one dope....amine!
How Stimulating
Modafinil
Methods and Results
100
What is the abbreviation for the the dopamine transporter?
DAT
100
What are three street names for cocaine?
Crack, snow, coke, etc.
100
Is Modafinil an agonist or antagonist?
Antagonist
100
What was the primary route of administration used by the subjects?
Smoking (Crack)
200
What are the three dopamine pathways?
Mesolimbic, Mesocortical, and Nigro-striatal
200
What is the quickest route of administration for cocaine?
Smoking (crack)
200
What transporter does Modafinil act on?
DAT
200
Which group exhibited higher levels of craving on the Brief Substance Craving Scale (BSCS)?
Placebo group
300
What enzyme converts L-DOPA to dopamine?
Aromatic L-amino acid decarboxylase
300
What are the two ways in which amphetamines increase dopamine levels in the synapse?
Stimulate more vesicular release and reverse DAT
300
In what country were the wakefulness-inducing properties of Adrafinil (Modafinil precursor) first discovered: France, USA, U.K., or Germany?
France
300
What test did they use to verify self-reported drug use?
Urine Benzoylecgonine Tests (UBT)
400
True or False: D1 receptors are excitatory (Gs), while D2 receptors are inhibitory (Gi).
True
400
True or False: MDMA is an amphetamine that, like the other amphetamines, acts on the neurotransmitter dopamine.
False
400
True or False: Modafinil is also used to treat Narcolepsy and Parkinson's disease.
False
400
True or False: Subjects were allowed to have a comorbid cannabis or nicotine dependence.
True
500
What happens when you have too little dopamine overall?
Tremors, problems initiating movement, depression, anhedonia, and anxiety.
500
What neurotransmitter transporter does cocaine bind to with the highest affinity?
5-HT/Serotonin/SERT
500
What is the antagonist that works to counteract most amphetamines, but does not work on Modafinil?
Haloperidol
500
What are two of the three side effects reported by the subjects?
Headaches, anxiety, and insomnia.
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