Monoferric PI Jeopardy

Round 1

100

Generic name for Monoferric?

ferric derisomaltose

200

Two words that describe Monoferric solution

Sterile, dark brown, non-transparent, aqueous

300

Monitor patients for signs and symptoms of hypersensitivity during and after Monoferric administration for at least 30 minutes and until what? 

Clinically stable following completion of infusion.

400

Adverse reactions were reported in ____________ percent of patients treated with Monoferric.

8.6

500

How much Monoferric should a 105 pound patient recieve? 

952 mg

Round 2

100

Year of Initial US Approval

2020

200

Indications for Monoferric

Treatment of IDA in ADULT patients who have intolerance or unsatisfactory response to oral iron, or patients who have non-hemodialysis dependent CKD.

300

In clinical trials with IDA & CKD, serious or severe HSRs were reported in what % of patients? This was what ratio of patients?

.3%

6/2008

400

Hypophosphatemia (serum phosphate concentration of ________) was reported in ___________percent of Monoferric treated patients in Trials 1 & 2.

<2 mg/dL in 3.5% 

500

Excessive iron therapy can lead to excess iron storage and possibly ___________  ____________ or __________________. 

iatrogenic hemosiderosis or hemochromatosis 

Round 3

100

Each mL of Monoferric contains this amount of elemental iron:

100 mg

200

Administer Monoferric by IV infusion over at least ________ as a ______  _______.

20 minutes; single dose

300

Monitor these iron parameters during parenteral iron therapy:

Serum ferratin, Transferrin saturation TSAT

400

What percentage of patients were 65 and older (200 points)?, what percentage of patients were 75 and over (200 points)?

29%, 13%

500

Describe Monoferric use in pregnant women (we all communicate this slightly differently, let's share!)

Share back.

Round 4

100

Administer 1000 mg of Monferric to patients weighing:

50 kg or more

200

Withdraw appropriate volume of Monoferric and dilute in what? Volume of this diluent? 

.9% sodium chloride injection, USP (regular saline); 100-500mL

300

The safety of Monoferric was evaluated in ____________ patients in two randomized, actively-controlled trials.

3008

400

When does serum ferratin peak after an IV dose of Monoferric?

7 days

500

How is Monoferric excreted? How is it NOT excreted? 250/250

Small quantities of iron are excreted in urine and feces. Not excreted via the kidneys?

Round 5

100

Volume of Monoferric vial in US

10 mL

200

Monoferric is contraindicated in patients with:

a history of serious hypersensitivity to Monoferric or any of its components.

300

How many patients were exposed to 1000mg single IV dose of Monoferric in the two trials?  BONUS for 100 points each: Patients exposed to Monoferric in Trial 1, patients exposed to Monoferric in Trial 2.

2008 / 1483 / 1525

400

Half-life of a single 2000 mg Monoferric dose?

27 hours.

500

Storage/handling conditions for Monoferric vial and infusion bag (list three things). 200 for 1, 400 for 2, 500 for 3.

Store at 20-25 degrees C (68-77 degrees F), do not freeze, store Monoferric/saline solution for up to 8 hours at room temperature.