Herpes
Child's rash caused by viremia found mostly in trunk of body. Presents with fever THEN rash.
HHV6 AKA Roseola
Prevented by live vaccine
V for VZV
What are the enzymes found in reverse transcriptase?
RdDp, DdDp, Rnase H
True/False: Primary Hepatocellular could be cured through recombinant subunit vaccine.
False, surgery
Own DNA dependent DNA polymerase
Herpes
Causes Neonatal severe disabilities, herpes meningitis, herpes encephalitis, eczema herpeticum, herpes whitlow, herpes pharyngitis, cold sore, fever, blisters, herpes gingivostomatitis
HSV 1 & 2
Can be diagnosed if triad is present. (High fever, lymphadenopathy, exudative pharyngitis) or shows Downy particles in blood sample.
EBV/Epstein-Barr
Hepadnavirus is unstable in the outside environment and will deteriorate when placed in a detergent.
False! Most stable enveloped virus, can withstand detergent.
HBsAg Negative
HBsAb Negative
HBcAg Positive
Window
Can integrate into Host DNA
Hepadnovirus
What does the antibody look like for a heterophile antibody positive patient look like and which virus does it present in?
Same Fc, Different Fab
EBV
HSV & VZV
(CHEVR-T3B3T)
How do we provide protection to the fetus against infection with HBV?
Passive Immunization
How and where does the partial DNA become whole?
Cytosol (Reverse Transcriptase)
Nucleus (Host DdDp)
Can be diagnosed by seeing syncytia or Cowdry Type A bodies.
This virus can be treated by acyclovir and valtrex.
What does it use and prohibit from the virus?
HSV 1 & 2
Thymidine kinase and Viral DdDp
Most common congenital defect, can cross the placenta, can see basophilic inclusion bodies (Owl eyes) under microscope.
CMV
A 25 year old man, Joseph, comes in with classical icteric symptoms and through labs is shown to have an excessive amount of HBsAg and HBsAb. He also shows symptoms of rash arthirtis, and glomerulonephritis. Which phase is Joseph most likely to be in?
Acute Infection
WHEN does HBcAb IgG show and what does it mean?
Core IgG‐ rises soon after IgM; remains present for life in chronic carriers and those who clear the infection; appears 3‐6 mo after infection
A child names Sadaf came in showing hepatosplenomegaly, seizures, and developmental issues. Which virus is she most likely to have?
CMV
This virus can cause an under-reactive T-cell response which can be visualized in a patient's jaw and face most commonly found in high malarial regions.
EBV (African Burkitt's Lymphoma)
This virus inhibits the tap channel which prevents MHC1 from binding to the antigen and therefore blocks immunity
HSV 1 & 2
Describe the steps of replication
Endocytosis->Completion of partial DNA(nucleus-Host DdDp, Cytosol- Viral Reverse Transcriptase)->DNA to RNA (Host DdRp) ->RNA to DNA (Viral RdDp) ->RNA removal (Viral RnaseH)->DNA to DNA (Viral DdDp)-> Exit cell patrially
HBsAg negative
HBsAb Positive
HBcAb Positive
Recovered
Reactivation of virus is found across the dermitome in a unilateral formation.
VZV