Classification Criteriaboot
Myositis Antibodies
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Random Questions
Genetics
100
This is the name of the old criteria for classification of inflammatory myositis.
What is the Bohan and Peter classification system?
100
This autoantibody is more associated with polymyositis, interstitial lung disease, Raynaud's, fevers and mechanic's hands.
What is anti-synthetase autoantibodies or JO-1?
100
This flower lent it's name to this pathognomonic rash of dermatomyositis. 
What is the heliotrope?
100
These are the two peaks of age of onset for dermatomyositis.
What is 50-15 years and 50-60 years?
100
This complex is not normally found in normal muscle but can be isolated from myositis muscle biopsies and is thought to play a role in pathogenesis.
What is Class I Major Histocompatibility Complex?
200
This is the age group that will yield the highest number of points for the 2017 ACR/EULAR Classification Criteria for myositis.
What is >/= 40 years old?
200
What is the antibody most associated with dermatomyositis and malignancy?
What is TIF-1-gamma?
200
These are the pathological features seen on this muscle biopsy from a patient with polymyositis.
What are perivascular inflammation, difference in muscle fiber size and migration of the nucleus into the center of the cell?
200
This myositis is more common in african americans than whites.
What is polymyositis?
200
These are potential environmental triggers for the development of an inflammatory myositis (name four that are not medications or viruses/bacteria/fungi).
What is UV light, silicone breast implants, collagen injection, smoking, silica, CGVHD?
300
This is the set of muscles that will yield the highest number of points in the 2017 ACR/EULAR MCC.
What are the neck flexors and neck extensors?
300
What is the antibody associated with polymyositis and may portent more severe disease, especially for the heart?
What is the signal recognition particle (anti-SNP)?
300
Cellular atrophy around the fascicle, vascular infiltration and inflammatory cells invading the fascicle are all characteristics of a patient with this disease.
What is dermatomyositis?
300
This is the percentage of patients who will have malignancy associated myositis?
What is 4-42%?
300
The pathway most significant for myositis in Asians.
What is the signal transducer and activator of transcription 4 gene (STAT4)?
400
This skin manifestation will yield the highest number of points on the 2017 ACR/EULAR MCC.
What is Gottron's sign?
400
What is the autoantibody most associated with juvenile DM, contractures and calcinosis?
What is anti-NXP-2/anti-MJ?
400
These sign is seen in patients with dermatomyositis.
What are Gottron's Papules and capillary hypertrophy?
400
This is the percentage of patients with myositis who will have a positive ANA.
What is 80%?
400
This is the haplotype most associated with myositis in African Americans.
What is HLA-DRB1*08
500
Name this finding on muscle biopsy that yields the highest number of points for muscle biopsy on the 2017 ACR/EULAR MCC AND the diagnosis.
What is rimmed vacuoles consistent with inclusion body myositis?
500
What are the four clinical features of having positive anti-MDA5/antiCAMD-140 antibodies associated with, particularly if one is Asian?
What are dermatomyositis, amyopathic disease, mucocutaneous lesions, severe lung disease.
500
A myositis patient with this EKG is most likely to have these autoantibodies present.
What is signal recognition particle?
500
The part of the GI tract that is most commonly involved in patients with myositis.
What is the esophagus?
500
These are the HLA haplotypes most associated with caucasian dermatomyositis patients.
What are HLA-DRB1*0301 and HLA-DQA1*0501?