Negative ≠ Failure
This term describes a study that does not demonstrate the expected benefit or fails to meet its primary endpoint.
What is a negative study?
This sarcoma drug received accelerated approval after promising early results but later failed to confirm a survival benefit.
What is olaratumab?
This nickname describes unpublished negative studies sitting unseen instead of entering the scientific literature.
What is the file drawer problem?
This is the main outcome a clinical trial is designed to evaluate.
What is the primary endpoint?
This was the name of the Phase III trial that failed to confirm olaratumab's benefit.
What is ANNOUNCE?
UCSF generally requires applicable primary results to be reported within this many months after the Primary Completion Date.
What is 12 months?
This occurs when published research disproportionately favors positive findings.
What is publication bias?
In the antidepressant example, this percentage of the published trials appeared positive.
What is ~94%?
This international ethical guidance states that negative and inconclusive research results should be made publicly available.
What is the Declaration of Helsinki?