Microanatomy
-What does the renal corpuscle consist of?
glomerulus and glomerular capsule
True or false: Glomerulus are extremely impermeable
False: Glomerulus are exceptionally porous, allows solute rich fluid to pass through into the glomerular capsule
What is the filtration membrane formed of?
It's formed by fenestrated endothelium of the glomerulus, a basement membrane and the podocytes of Bowman's capsule.
What is the order of the three major parts of the renal tubule?
-Proximal convoluted tubule (PCT)--Nephron Loop--Distal Convoluted Tubule (DCT)
Function of DCT and Collecting Duct?
-Reabsorption is hormonally regulated--Ca2+(PTH), Water (ADH), and Na+ (Aldosterone and ANP)
What are the two major groups of the nephron?
Cortical and Juxtamedullary
True or False: Cortical nephron is a short loop
True
Podocytes interdigitate form what?
Podocytes form filtration slits
What is the Proximal convoluted Tubule?
-PCT- Functions in absorption and secretion, confined to the cortex.
Site of Reabsorption with 65% of Na+ and water, all nutrients, ions, and small proteins.
-PCT
What are the layers in the glomerular capsule?
Parietal and visceral
What layer of the glomerular capsule contains podocytes?
Visceral layer
Podocytes interdigitate with what other structure to form filtration slits?
Pedicels
What is the Loop of Henle?
-Thin segment usually within the descending limb. Freely permeable to water and thick segments of ascending limb.
The Loop of Henle Ascending Limb functions Na+, K+ and ___.
Cl-
Uniquely shaped cells with finger-like arms that cling to the basement membrane of the glomerulus is known as
Podocytes
Another name for a glomerular capsule is?
Bowman’s Capsule
What are filtration slits?
Filtration slits are leaving small gaps between the digits to form a sieve.
Functions more in secretion than reabsorption and confined to the cortex.
-DCT-Distal Convoluted Tubule
The Nephron Loop has what limbs?
-Descending and Ascending
What type of epithelium tissue is the glomerular capsule parietal layer made of?
Simple Squamous Epithelium
The renal tubule is associated with two beds of capillaries, what is the first capillary bed?
Glomerulus
The podocytes filtration slit prevents filtration of what?
Blood cells and Large proteins
Receive filtrate from many nephrons and fuses together to deliver urine through papillae into minor calyces.
-Collecting Ducts
Segments of Collecting Tubules:
-Cortical, Medullary, Papillary