gMG, yea you know me
This number of gMG cases have detectable levels of anti-AChR antibodies, which activate complement
What is 85%
Anti-AChR Antibodies trigger activation of complement through this pathway
What is the classical pathway?
These therapies work by binding and depleting
B cells, thereby preventing B-cell activation and proliferation
What are B cell inhibitors?
This percentage of patients may not fully recover from their first NMOSD clinical event
What is 76%
These work by inhibiting terminal complement and preventing formation of the MAC and astrocyte damage
The MOST SENSITIVE test for AChR and MuSK autoantibodies
What is cell-based assay (CBA)?
This leads to membrane destruction
over time
What is Complement Activation?
These therapies inhibit terminal complement and prevent formation of the MAC at the NMJ
What are complement inhibitors?
The female to male ratio in NMOSD
What is 5:1?
These therapies work by binding and depleting
B cells, thereby preventing B-cell activation and proliferation
What are B-cell inhibitors?
The most troublesome symptom reported by patients
What is fatigue?
A decreased number or function of these impacts muscle control in patients with gMG
What is AChRs?
This blocks FcRn receptor and reduces circulating IgG levels
What are FcRn inhibitors?
NMOSD in patients of this ancestry is characterized by earlier onset, increased severity of relapses, and increased mortality
What is African ancestry?
This therapy leads to T-cell inactivation, B-cell and autoantibody reduction
What is IVIG?
This percentage of patients with ocular symptoms progress to generalized symptoms
What is 75%?
The reduced function or number of AChRs causes a reduction in this, resulting in impaired muscle contraction
What is EPP generation?
This therapy works by T-cell inactivation, B-cell and autoantibody reduction
What is IVIG?
The primary site of damage in NMOSD
What are astrocytes?
These therapies work to inhibit enzymes to reduce protein synthesis or action at lymphocytes
This leads to depolarization of
the muscle membrane and muscle contraction
What is binding of ACh to AChR?
In gMG, these cells secrete
anti-AChR antibodies that target the NMJ
What are plasma cells?
These therapies interfere with cellular synthesis, replication, and proliferation; inhibiting interleukin synthesis
What are immunosuppressants?
In patients with NMOSD, these
bind to AQP4 and initiate formation of lesions via complement activation
What are anti-AQP4 antibodies?
These therapies work to reduce plasmablast survival, AQP4 antibody production, BBB deterioration, and pathogenic Th17 cell differentiation
What are IL-6 inhibitors?