Neurogenesis
Methods
Acronyms
Results
Mystery
100
Adult hippocampal neurogenesis occurs in this studied area of the brain
What is the dentate gyrus?
100
This compound was used as the ‘labelling’ compound in the pulse-chase experiments
What is BrdU?
100
A label for progenitor stem cells
What is DCX?
100
The number of times a mouse exhibits this physical action was used as measurement for exploratory behavior.
What is a rearing event?
100
A compound used in this study to label DNA
What is Hoechst?
200
This percentage of young adult-born neurons undergo apoptosis
What is 60-80%?
200
This plus-shaped apparatus was used to measure anxiety-like behaviors in mice
What is an Elevated Plus Maze
200
EYFP
What is enhanced yellow fluorescent protein?
200
Quantification of this molecule shows an increase in tertiary dendritic growth in NCff+TAM mice
What is DCX?
200
This item of food was used by Sam to describe the relationship between BrdU-labelled NeuN labelled cells
What is a pizza (medium and x-large)?
300
Inhibited apoptosis allows for the increased number of this type of fully developed neuron
What is a tertiary dendritic cell?
300
This part of the foot received electric shock during the method for figure 2, to determine pattern separation for different environmental contexts.
What is the Foot
300
This acronym was used to describe a ROSA26fstopEYEP/+ mouse in which young adult neuronal apoptosis still occurred
What is NCY?
300
NCff+TAM Mice exhibit this behavior less, but over-time when placed in a new but similar context from which they were shocked.
What is Freezing?
300
This compound is a known analog of BrdU, which was mentioned in this presentation
What is thymidine?
400
This stem cell marker is expressed by neural cells during the development of axons
What is Nestin?
400
This gene was incorporated as an EYFP reporter line into the NCY and NCffY mice.
What is ROSA26
400
iBAXNes
What is a NCff mouse injected with Tamoxifen?
400
This type of conditioning/ learning involves applying a sock in a context, and then repeatedly placing the mouse in a similar context and presenting no shock, so that it no longer predicts the coming of the shock. With this, mice expecting the shock gradually stops.
What is pattern separation?
400
This virus encodes the Cre enzyme, which is widely used to carry out cell-specific or time-specific DNA recombination by flanking the target DNA with loxP sites.
What is Bacteriophage P1?
500
Increasing ______ _______ ______ is ______ to _______ _________ _______
What is adult hippocampal neurogenesis, sufficient, improve pattern separation?
500
This part of the mouse was injected with tamoxifen to determine the effects of increased hippocampal neurogenesis
What is the Peritoneal Cavity
500
Double Jeopardy
?
500
This specific y-axis label was used in supplementary figure 19A to describe the percentage of exploratory behavior outside of the center of the cage. There was no difference among NCff-TAM or NCff controls for this measure.
What is % pathlength Center?
500
Fluoxetine, a medication mentioned in the paper, is known for enhancing LTP (long term potentiation) and is a drug belonging to this class of antidepressants.
What is an SSRI?
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