Motor Malfunctions
The triad of Miller-Fisher syndrome and associated antibody.
Opthalmoplegia, arreflexia, and ataxia
Anti-GQ1b
This 4-year-old female was developmentally normal until age 2 at which time she was hospitalized with a febrile illness. Over the last 2 years she has experienced regression of milestones, refractory seizures, and this is her most recent MRI.
Vanishing White Matter Disease
The difference between a epileptic encephalopathy and a developmental epileptic encephalopathy.
This phenomena can lead to an ipsilateral CN3 palsy and contralateral weakness in a patient with increased ICP
Uncal herniation
Acute migraine treatment option for a patient with a history of heart disease.
Aspirin
These infectious agents are potential antecedent causes of GBS. (4)
Campylobacter jejuni
Hepatitis E
Cytamegalovirus
EBV
Mycoplasma pneumoniae
Zika virus
Dengue virus
Chikungunya virus
This condition causes excess deposits of cholesterol and cholestanol in both the central and peripheral nervous system as seen in this image.
Name 3 medications used in status epilepticus and their doses.
Dilantin 20mg/kg
Valproic Acid 40mg/kg
Keppra 60mg/kg
Lacosamide 400 mg
This EEG pattern might be seen in the ICU.
Burst Suppression
Criteria for a diagnosis of Tourette syndrome.
At least one phonic tic and two or more motor tics present in patients for at least 1 year before the age of 18 years.
Mutation associated with frontotemporal dementia and ALS.
C9orf72
This complexion can be seen in this particular leukodystrophy.
Adrenoleukodystophy
This time point marks established status epilepticus.
This time point marks refracctory status epilepticus (continued status due to failure of two adequately dosed ASMs of different drug classes)
This time point marks super-refractory status epilepticus (continued status despite the use of anesthetizing ASM medications)
5 minutes
30 minutes
24 hours
A 40-year-old male presents with fever, possible seizures, and altered mental status. These medications should be started prior to lumbar puncture.
Vancomycin
Ceftriaxone
Acyclovir
Localization for loss of sensation to the dorsum of the foot with impaired dorsiflexion and inversion.
Common peroneal nerve
This rule is used to provide cutoff values for risk assessment of respiratory failure.
The "20/30/40 rule" — risk of respiratory failure if:
Vital capacity < 20 mL/kg
Maximum inspiratory pressure < 30 cm H₂O
Maximum expiratory pressure < 40 cm H₂O
Not to be confused with the trappings of Joey Exotic, this MRI pattern is seen in this leukodystrophy.
Metachromatic leukodystrophy
A 4-year-old child with a history of prolonged febrile seizures and mild developmental delay presents in status epilepticus. Name a condition you could be suspicious of and which loadable ASM you should avoid.
Dravet Syndrome
Dilantin (also carbamazepine, oxcarbazepine, lamotrigine, and other sodium-channel blockers)
Name the neurologic emergency and associated finding.
Basilar Artery Occlusion/Hyperdense Basilar Artery Sign
Movement and neurocognitive treatment-emergent adverse events refer to side effects of this type of treatment.
CAR-T targeting BCMA
Mechanism of action of tofersen.
Antisense oligonucleotide to SOD1
POLR3-Related Leukodystrophy is also known as "4H Syndrome" based on these findings.
Hypomyelination, Hypodontia, and Hypogonadotropic Hypogonadism
This ASM should be used in patient's with epilepsy associated with this skin finding.
Vigabitran
Explain these eye findings.
Subacute R tonic pupil, light near dissociation
A - darkness; right pupil is slightly smaller than left
B - in the light, the left pupil constricts but the right responds poorly
C - with accommodation, the right pupil constricts well, indicating aberrant regeneration of postganglionic parasympathetic fibers
The discovery of this paraneoplastic condition has strong ties to the province of Saskatchewan. Name the antibody, associated cancer, and general clinical presentation associated with Opthelia sydnrome.
mGluR5
Hodgkins lymphoma
Memory dysfunction, behavioural changes, psychiatric symptoms, hallucinations, seizures