Sweetsie Pie
You down with Pyo-G, yea you know me!
100
In a patient with history of malignancy associated Sweets Syndrome, what does re-appearance of the dermatosis mean?
Possible recurrence of malignancy.
100
What is PAPA syndrome and what is its gene?
Pyogenic Arthritis, Pyoderma gangrenosum, Acne PSTPIP1 gene that encodes CD2 binding protein 1. Auto Dominant.
200
Name 3 systemic treatments for Sweets Syndrome.
Systemic corticosteroids, potassium iodide, dapsone, and colchicine.
200
What type of cell is found at the edge of the PG ulcer?
T cells.
300
What is the recurrence rate of Sweet’s syndrome?
30% (with or w/o tx). 50% in immunocompromised.
300
In a patient with cutaneous PG, where else can you get sterile neutrophilic abscesses?
Lung, joints, CNS, CVS, intra-abdominal viscera, eye
400
Name 2 Major criteria and 2 Minor Criteria for Sweets Syndrome.
Major: (1) Abrupt onset of painful juicy plaques, (2) Histopath showing dense neutrophilic infiltrate without LCV. Minor: (3) Fever, (4) Association with malignancy (AML, GU, breast, GI), IBD, Pregnancy, Infection (URI, GI), or vaccination. (5) Rapid response to systemic steroid or KI, (6) Abnormal labs – ESR, CRP, WBC, neutrophilia.
400
What type of monoclonal gammopathy are neutrophilic dermatoses most commonly asst with?
IgA monoclonal gammopathy
500
In histiocytoid sweets, what do the histiocytoid cells stain with?
MPO (myeloperoxidase)
500
Name several entities associated with an IgA gammopathy.
Sneddon Wilkinson, Sweet’s, PG, EED, IgA Pemphigus, POEMS.
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