AstraZeneca Proprietary Compounds
AstraZeneca's largest blockbuster drug that brought in $6.58 billion in 2024 and treats non-small cell lung cancer.
What is Tagrisso (Osimertinib)?
This app allows you to order breakfast and lunch from the cafeteria directly on your phone.
What is Thrive?
This acronym refers to the detailed, written instructions AstraZeneca teams follow to ensure consistency and compliance in tasks such as laboratory operations, clinical trial conduct, or manufacturing.
What is SOP (Standard Operating Procedure)?
Widely considered the first slasher film, this 1978 movie features a masked villain named Michael Myers terrorizing the town of Haddonfield on the night of October 31st.
What is Halloween?
This type of protein, often targeted by drugs, lowers the activation energy required for a particular reaction.
What is an enzyme?
This recently FDA-approved antibody-drug conjugate from AstraZeneca, developed in partnership with Daiichi Sankyo, treats advanced HER2-low breast cancer by using a monoclonal antibody to deliver a cytotoxic agent directly to cancer cells.
What is Enhertu (trastuzumab deruxtecan)?
The physical location an AstraZeneca employee may frequent for all their computer, device, or password technical issues at GHP.
Where is the 2nd level Atrium (AskIT)?
In modern oncology drug development, AstraZeneca often pursues this kind of therapeutic, which combines antibodies with cytotoxic agents to target cancer cells more precisely.
What is ADC (Antibody-Drug Conjugate)?
The classification for a particular group of trees that shed their leaves annually, resulting in vibrant yellow, red, and orange leaves during fall.
What is deciduous?
This property describes a drug's ability to dissolve in fat, affecting its absorption and distribution in the body.
What is lipophilicity? (LogD)
This AstraZeneca compound is a proton pump inhibitor used to treat acid-related disorders, such as acid reflux and heartburn.
What is esomeprazole (Nexium)?
This site or app helps users to navigate to a site, book meeting rooms, and desks.
What is Companion?
This acronym refers to studies designed to analyze the absorption, clearance, biomarker modulation, and other parameters of drug kinetics.
What is PK/PD? (Pharmacokinetics/Pharmacodynamics)
One of the most easternly point of the continental United States, where you can hike to the summit to watch the sunrise on a clear morning.
What is Cadillac Mountain (Acadia National Park)?
These AI tools use deep learning to generate human-like text and understand human language by analyzing vast datasets.
What are large language models (LLMs)?
Granted FDA approval in early 2024 for advanced ovarian cancer patients with BRCA mutations, this PARP inhibitor from AstraZeneca is often used as maintenance therapy post-chemotherapy.
What is Lynparza (olaparib)?
One of the most commonly booked spaces for large meetings, this room's nickname stems from the speech of a common farm animal.
What is M00.08? (MOO-8)
What is a CRO? (Contract research organization)
Born on October 31st, 1967, This iconic 90s rapper topped the charts with his hit song "Ice Ice, Baby" under the stage name Vanilla Ice.
Who is Robert Matthew Van Winkle?
This term refers to one of AstraZeneca's key decision-making stages for a compound, in which chemical modifications are made to a drug’s structure to optimize its potency, selectivity, and safety during preclinical development.
What is lead optimization?
This first-in-class SGLT2 inhibitor from AstraZeneca, approved by the FDA for type 2 diabetes and heart failure, is also being investigated for chronic kidney disease.
What is dapagliflozin (Farxiga in the US)?
Located in the dungeons of the AstraZeneca Waltham site, this room hosts the nurses office.
What is D00.09?
This acronym is used to describe the complex mixture of activities and documentation ensuring drugs are manufactured to the highest standards before release, a key function in AstraZeneca’s supply chain.
What is CMC (Chemistry, Manufacturing, and Controls)?
This ancient festival, celebrated at the end of October by Celtic peoples, is considered the origin of modern Halloween traditions.
What is Samhain?
This regulatory parameter, calculated as the ratio of a drug’s maximum tolerated dose (MTD) to its minimum effective dose, helps determine its safety margin for use in humans.
What is therapeutic index?