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A 45-year-old man with long-standing, poorly controlled type 2 diabetes mellitus presents with chronic generalized fatigue. Laboratory evaluation reveals: serum pH 7.31, PaCO2 32 mmHg, serum HCO3- 16 mEq/L, serum Na+ 138 mEq/L, and serum Cl- 110 mEq/L. His urine anion gap is positive, and serum potassium is elevated at 5.4 mEq/L. Which of the following is the most likely underlying mechanism for his acid-base disturbance?
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A 58-year-old man with persistent atrial fibrillation and heart failure with reduced ejection fraction (HFrEF) is started on a new antiarrhythmic drug. Six months later, he develops progressive dyspnea, dry cough, and diffuse interstitial infiltrates on chest X-ray. Liver function tests show transaminitis, and his TSH is elevated at 8.2 mIU/L. Which of the following drugs is most likely responsible for this multiorgan presentation?
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