Breaking Brain
The term for greatly reduced blood flow.
Ischemia
Degeneration of the nigrostriatal pathway is a hallmark of this disease.
Parkinson's Disease
This toxin acts as a protease and cleaves SNARE proteins in cholinergic neurons.
Botulism
This seizure type originates from widespread regions on both hemispheres.
Generalized
This disorder is caused by an unstable CAG/CAA repeat expansion encoding a toxic polyglutamine tract.
Huntington's Disorder
Impaired BBB that leads to accumulation of fluid and protein in the interstitial space
vasogenic edema
Immune-mediated CNS demyelination is associated with this disease.
Multiple Sclerosis
This area of the brain is associated with the preoccupation with substance use.
PFC
This process results in the death of GABAergic interneurons and increased axon sprouting in glutamatergic neurons.
Epileptogenesis
This phenomenon refers to the fact that α-motor neurons at the NMJ release way more ACh than needed to cause muscle contraction.
The Safety Factor
This condition results in high CRP (blood), immune cells (blood/CSF), and pressure (CSF).
Bacterial Meningitis
This disease causes degeneration of cholinergic neurons throughout the cortex, amygdala, and hippocampus.
Alzheimer's Disease
Once tolerance develops with an AUD this happens to the excitability of the CNS.
It increases (becomes hyperexcitable)
Deficiency in this transporter results in decreased glucose transport across the BBB.
GLUT1
A patient who has skeletal muscle weakness and fatigue that worsens with activity but improves with rest should be assessed for this disease.
Myasthenia Gravis
This area is not damaged initially after a stroke, but is at risk if treatment is not given.
penumbra
The presence of APOE4 variant increases this process.
amyloidogenesis (plaque build-up)
MOR activation on GABAergic interneurons in VTA leads to this.
disinhibition of DA cells =↑ NAc dopamine
This disorder is associated with increased Na+ influx that causes increased electrical excitability of muscles and muscle stiffness.
Myotonia
ALS
This damaging neuronal firing response results from an injury that reduces O2 or glucose availability to cells.
Lewy body formation that initially begins in the hindbrain but spreads to other parts of the brain is associated with this disease.
Parkinson's Disease
This toxin results in loss of transmitter release (gly) at spinal inhibitory interneurons.
Tetanus
Increased electrical excitability of the cerebellum due to a loss of function K+ channel mutation results in this disorder.
Episodic ataxia type 1 (EA1).
In this disease antibodies produced by body bind to and block voltage-gated Ca2+ channels on pre-synaptic cell.
Lambert-Eaton Syndrome