Theranostics Basics
This term describes the use of radioactive compounds for both imaging and treating disease in nuclear medicine.
What is theranostics?
This radioisotope is a dual beta- and gamma-emitter, primarily used for both therapy and diagnostic scanning in thyroid cancer.
What is Iodine-131?
This imaging technique uses 68Ga-labeled analogs to improve diagnosis and staging of neuroendocrine tumors.
What is Somatostatin Receptor (SSTR) PET?
This process ensures patients make voluntary, educated decisions about their medical care.
What is informed consent?
This phenomenon describes the shrinkage of distant metastases after local radiation treatment.
What is the abscopal effect?
Paul Ehrlich's concept of a drug that targets diseased cells without harming healthy ones is called this.
What is the "magic bullet"?
This positron-emitting isotope is used in PET imaging for high-resolution dosimetry studies in thyroid cancer.
What is Iodine-124?
This theranostic approach delivers radioactive microspheres to liver tumors via arterial vasculature.
What is hepatic radioembolization?
Physicians must explain these potential outcomes if a patient refuses a radiation oncology procedure.
What are the consequences of refusal?
This imaging technique combines PET or SPECT with CT to provide both functional and anatomical information.
What is hybrid imaging?
The primary goal of theranostics in nuclear medicine is to provide this type of customized healthcare.
What is precision oncology?
This alpha-particle emitting isotope is used to treat bone metastases from prostate cancer, improving survival and reducing pain.
What is Radium-223 (223Ra)?
PSMA PET is highly effective for this type of prostate cancer due to its sensitivity in detecting small lesions.
What is metastatic castration-resistant prostate cancer (mCRPC)?
This standard determines the level of detail a physician must disclose, based on what a typical person would want to know.
What is the reasonable person standard?
This side effect, also known as dry mouth, is a dose-limiting toxicity in some theranostic treatments.
What is xerostomia?
This type of radiation, emitted by isotopes like Iodine-131, is used for therapeutic treatment by delivering cytotoxic energy to diseased tissues.
What are alpha or beta particles?
This beta-particle emitting isotope is paired with Copper-64 for therapeutic applications in theranostics.
What is Copper-67 (67Cu)?
This radiopharmaceutical, labeled with Iodine-131, targets neural crest-derived tumors like neuroblastoma.
What is Metaiodobenzylguanidine (MIBG)?
This exception allows a physician to withhold information if it could cause a substantial adverse impact on a patient’s health.
What is therapeutic privilege?
This term refers to differences in phenotypes and genotypes within a tumor, impacting treatment response.
What is tumor heterogeneity?
This classic theranostic system, using radioiodine, was the first successful example for treating differentiated thyroid cancer.
What is Iodine-131-based diagnosis and therapy?
This isotope, often used with somatostatin analogs like DOTATATE, is a beta-emitter for treating neuroendocrine tumors.
What is Lutetium-177 (177Lu)?
Bone-seeking radiopharmaceuticals like 153Sm-EDTMP target this component in metastatic bone lesions to alleviate pain.
What are hydroxyapatite crystals?
This patient right allows them to request not to be fully informed of certain risks or facts.
What is patient declination?
This cancer cell behavior, targeted by FDG PET, involves preferential use of aerobic glycolysis for energy.
What is the Warburg effect?