NOC Importance
Considerations in NOC
Methods
Blast from the Past
Movie Trivia
100
May produce weak support for inclusion for non-contributors
What is overestimating the NOC?
100
Degraded, inhibited, stochastic effects and a noisy baseline are signs of what
What are signs of poor quality?
100
Uses the number of peaks at a locus.
What is Maximum Allele Count (MAC)?
100
Primary output of STRmix.
What are weights?
100
Who is Leonard Nimoy (Spock)?
200
May lead to false exclusions of true contributors.
What is underestimating the NOC?
200
May be determined by Allele Average Method, Allele Regression Method or Longest Uninterrupted Stretch (LUS) Method.
What is Stutter ratio?
200
Uses the number of peaks combined with allele frequencies.
What is Maximum Likelihood Estimation (MLE)?
200
Confuses the probability of the evidence with the probability of the hypothesis itself.
What is transposed conditional?
200
This film used DNA obtained from mosquitoes to recreate an extinct population.
What is Jurassic Park?
300
Generally effects weak or trace contributors
What is underestimating or overestimating the NOC?
300
Spikes, pull-up, stutter peaks, non-specific amplification products, elevated baseline noise, minus A, drop-in and drop-out are examples of what.
What is Artifacts?
300
A software from makers of STRmix that estimate the number of contributors in a mixture.
What is FaSTR DNA?
300
The view after the DNA evidence is presented.
What is posterior odds?
300
In this film a women inherits a planet based on her genetic code.
What is Jupiter Ascending?
400
No significant impact for strong contributors.
What is overestimating the NOC?
400
This should be used sparingly since it cannot be directly compared
What is Variable NOC (varNOC)?
400
A computational tool that uses Bayesian Methods to calculate the probability distribution for the NOC.
What is NOCIt?
400
How Hb is always calculated
What is the Observed RFUs of HMW peak over the Observed RFUS of LMW peak?
400
In this film of a bleak future Earth, a soldier endures a radical genetic transformation in order relocate the human race to a distant moon.
What is The Titan?
500
May decrease the likelihood ratios by 2-3 orders of magnitudes for week or trace contributors?
What is overestimating the NOC?
500
The following should be reviewed on the STRmix output regarding N assignment
What is mixture proportions and weights, other diagnostics (i.e. allele variance) and counter-intuitive results?
500
A STRmix tool that allows for a narrow range of contributors to be considered.
What is Variable NOC (varNOC)?
500
Mathematical explanation for a biological process.
What is Biological Modeling?
500
In this 1997 film, children were conceived through genetic selection and their potential was assigned at birth.
What is GATTACA?