Teratogens
Class of medications that can impact renal perfusion and development leading to anuria, oligohydramnios, etc.
What are ACE inhibitors?
Pr/Cr ratio that reliably indicates a 24h urine protein of less than 300 mg.
What is <0.15?
Most common congenital infection with most frequent severe sequelae being hearing loss.
What is CMV?
Prophylactic dose of Anti-D immune globulin prevents alloimmunization after exposure of up to this fetal blood volume.
What is 30 mL?
These three labs constitute a work-up for antiphospholipid antibody syndrome.
What are lupus anticoagulant, beta-2 glycoprotein, anticardiolipin antibody?
Gestational age range where exposure to a teratogen is most likely to cause a major malformation.
What are weeks 3-8, the embryonic period?
Daily Double!
Three causes of secondary hypertension which accounts for about 10% of cases of chronic hypertension.
Fetal surveillance strategy following maternal infection with parvovirus.
What is serial ultrasounds q1-2 weeks to include MCA Doppler velocimetry studies for 8-12 weeks after exposure?
Daily Double!
Four situations that justify Rh D immune globulin administration.
Most prevalent inherited thrombophilia in the US population.
What is Factor V Leiden heterozygote status?
Exposure to this folic acid antagonist can lead to craniosynostosis, micrognathia, and limb abnormalities.
What is methotrexate?
Magnesium dose for recurrent seizure in a patient with preeclampsia on magnesium.
What is an IV bolus of 2-4 grams administered over five minutes?
Initiation of this oral agent within 24h of developing a varicella rash has been shown to reduce lesion formation and constitutional symptoms but not prevent congenital infection.
What is acyclovir?
Other members of the Rh family, aside from D.
What are E and C?
Two reasons to screen for inherited thrombophilias in a pregnant patient, according to ACOG.
What is a personal history of a VTE with no prior testing or a first degree relative with a history of a high risk inherited thrombophilia?
Rare (1-2:1,000 term infants) condition that develops after third trimester exposure of this class of medications; characterized by high pulmonary vascular resistance, right-to-left shunting, and profound hypoxemia.
What are selective serotonin reuptake inhibitors (SSRIs)?
Three high risk factors recognized by the USPSTF justifying low dose aspirin use.
What are prior preeclampsia, multifetal gestation, chronic hypertension, pregestational DM, renal disease, and autoimmune disease?
Preferred starting gestational age to perform amniocentesis for evaluation of congenital CMV.
What is 21 weeks gestation?
Frequency to monitor titers for a non-Kell antibody if <1:8.
What is every four weeks?
Two inherited thrombphilia labs you can order in a pregnant patient with an active VTE on anticoagulation.
What is a Factor V DNA testing and prothrombin gene testing?
Medication classically attributed to Ebstein anomaly though newer research doesn’t suggest a link.
What is lithium?
Rationale for obtaining a screening ECG for pregnant patients with chronic hypertension.
What is to evaluate for left ventricular hypertrophy?
Preferred agent for treatment of toxoplasmosis infection, if you can get it.
What is spiramycin?
Explanation for the severity of hemolytic disease due to Kell alloimmunization.
What is attacks red blood precursors in the bone marrow in addition to circulating mature red blood cells?
D-dimer cut off below which a PE is ruled out, assuming no 'YEARS' criteria.
What is a D-dimer <1,000 ng/mL?