Psychopharm monitoring
This mood stabilizer requires monitoring of serum levels, TSH, and renal function. It is renally cleared and has a narrow therapeutic index
What is lithium?
This triad of confusion, ophthalmoplegia, and ataxia results from Thiamine deficiency
What is wernicke's encephalopathy?
Per DSM 5, this disorder is distinguished from schizophrenia by a total symptom duration of at least one day but less than one month
What is brief psychotic disorder?
Per ACEP (American College of Emergency Physicians), in new onset psychosis without focal neurological deficit, routine use of this acute imaging study is not mandated
What is CT/brain neural imaging?
Both ketamine and psilocybin are proposed to converge on this neurotrophic receptor, signaling pathway to drive rapid synaptic plasticity
What is BDNF-TrKB pathway?
Carbamazepine's capacity to lower levels of co-prescribed psychotropics is explained by its potent induction of this hepatic enzymes system
What is cytochrome P450 system? (or CYP3A4 induction)
This delusional misidentification syndrome involves the belief that a familiar person has been replaced by an identical imposter
What is Capgras syndrome?
This diagnosis requires that delusions/hallucinations persist for at least two weeks in the absence of a major mood episode, while mood at symptoms are present for the majority of the illness
What is schizo affective disorder?
Lorazepam and this high potency typical antipsychotic are classic first line agents, alone or combined, for the acutely agitated patients
What is haloperidol?
Psilocybin exerts its psychedelic effect primarily as an agonist at this serotonin receptor sub type
What is 5HT2A receptor?
Fluoxetine and paroxetine are strong inhibitors of this CYP isoenzyme, which metabolizes many antidepressants and antipsychotics, and carries clinically important polymorphisms
What is CYP2D6?
This syndrome, "the delusion of doubles " involves believing a stranger is a familiar person in disguise who changes appearance
What is Fregoli syndrome?
Rapid mood shifts tied to interpersonal dysfunction, and a core disturbance in attachment, favor this diagnosis over bipolar disorder
Which is borderline personality disorder?
This novel dissociative agent was subject of an ACEP's (American College of Emergency Physicians) critical question regarding safety and efficacy for sedation of the severely agitated patient
What is ketamine?
Ketamine is taught to disinhibit glutamic neurons by blocking NMDA receptors preferentially located on these inhibitory interneurons
What is GABAergic interneurons?
This antipsychotic requires a REMS program with a mandatory ANC monitoring
What is clozapine?
This motor syndrome was first delineated by Karl Kahlbaum
What is Catatonia?
Amplification of anxiety, dysphoria, instability after an antidepressant is started should raise suspicion of this underlying disorder
What is bipolar disorder?
Before discharging a suicidal or potentially violent patient from the ED, the clinician must document this type of structured evaluation, weighing both protective and risk factors
What is suicide/violence risk assessment?
D serine and D cycloserine act as agonists at this modulatory site at NMDA receptor complex
What is the glycine modulatory site?
The combination of mirtazapine and quetiapine was the drug pair that was most frequently flagged for this QT related ad adverse effect in EudraViligance interaction reports
What is tachycardia/QT prolongation?
This rare condition involves a fixed delusional belief that one is already dead or does not exist (nihilistic delusion)
What is Cotard syndrome?
This acute neural cognitive condition (featuring vivid, hallucinations, fluctuating course, and acute onset) must be excluded before diagnosing a primary psychotic disorder
What is delirium?
This landmark California case established the clinician duty to protect identifiable third-party threatened by a patient.
What is Tarasoff v Regents of the University of California?
This CYP isoform, expressed in the brain, participates in alternative biosynthesis of dopamine and serotonin and is considered a potential CNS target
What does CYP2D6?