Response
This number of loci are utilized to measure TMS in the current version of Response.
What is 500?
Methyl groups are added to this amino acid in eukaryotes.
What is cytosine?
84
What is aneuploidy?
This is what QCT stands for.
What is Quantitative Counting Templates?
While imaging is standard of care for monitoring therapy response, these three situations can complicate matters.
What are psuedoprogression, scar tissue, and low contrast tissues?
In the setting of cancer, methylation does this to tumor suppressor genes.
What is silence?
Detection of this class of alterations is a differentiator for Northstar Select when compared to most on market therapy selection assays.
What is copy number losses?
The selective increase of certain genes in a cell.
What is focal amplification?
The discipline of math utilized to solve for the multiplier of QCTs, allowing BTO to quantify the starting material.
What is algebra?
Methylation shows the greatest improvement in precise detection over VAF-based methods when the VAF is ______.
What is low?
What is hypermethylation?
LOD95 refers to this.
What is the concentration that is detected in at least 95% of the replicates?
Treatments aimed at stabilizing chromosomal integrity may be important for tumors exhibiting _______.
What is aneuploidy?
This assay utilizes QCTs to directly quantify the output.
What is Response?
Tumor-informed therapy response monitoring assays face these three challenges.
What are longer TAT, tumor heterogeneity/clonality, and VAF-based measurements?
What is high assay noise?
The number of patients with orthogonal reports analyzed in the Select clinical validation study.
What is 182?
This percentage of cancers are estimated to exhibit aneuploidy.
What is 90%?
This makes QCTs amplify at the same rate as genes of interest.
What is similar sequences as genes of interest?
Our initial therapy response monitoring data with Response is in this tumor type with these treatment conditions.
What is NSCLC with ICI therapy?
Northstar Response reports include these 3 pieces of information in the results section.
What are TMS, change call, and fold change?
This VAF% is where Northstar Select saw the largest detection gains of SNVs/Indels in the clinical validation study.
What is below 0.5%
Genes with copy number signal indicating potential for aneuploidy can be found here on a Select report.
What is below Variants of Unknown Significance and just above Interpretation?
QCTs are added at these steps when running Select.
What are Extraction, Library Prep, and Target Enrichment?