Hard-ish
Name some clinical manifestations of gouty arthritis
- severe pain
- redness
- swelling
- abrupt onset
Allpurinol inhibits what ?
Xanthine oxidase
What is the normal uric acid range
2.4-7 mg/dL
What are some complication signs of Pericardiocentesis
Hemothorax, pneumothorax, coronary artery puncture
What is caused by cancer-related pericardial effusion compressing the heart?
Malignant Pericardial Tamponade
What are some signs and symptoms of malignant pleural effusion ?
Worsening dyspnea
Orthopnea
Dry Cough
What are some clinical signs of DIC ?
Microemboli
Hemorrhage
Organ Dysfunction
Cairo-Bishop Criteria
- Lab TLS: 2+ of: UA, Potassium
- Dysrhythmia
- Seizures
What are some TLS risk factors ?
- Hematologic malignancies
- Solid Tumors
- High Tumor burden, Rapid proliferation, cytotoxic therapy
- CKD, Dehydration, acidic urine
Rasburicase converts uric acid to what ?
Allantoin
What is the biochemical pathway of hyperuricemic syndromes ?
Purine -> Hypoxathine -> Xanthine -> Uric Acid
Plus 1578 points for choosing this one