Bevacizumab is the generic name for this blockbuster monoclonal antibody targeting HER2
What is Herceptin
100
Hodgkin’s Disease is a type of this hematologic cancer
What is lymphoma?
100
Abbreviated PCR, this technique is the foundation for most molecular diagnostics currently in use
What is PCR?
100
The target for BMS’s blockbuster monoclonal antibody therapy nivolumab
What is PD-1?
100
The generic name of Bayer’s tyrosine kinase inhibitor Nexavar
What is sorafenib?
200
Tarceva and Iressa are indicated for lung cancers carrying mutations in this gene
What is EGFR
200
Rituximab is indicated for treatment of lymphomas derived from this type of lymphocyte
What is B cell?
200
Abbreviated IHC, this technique is used to detect specific proteins in tumor tissue sections
What is immunohistochemistry?
200
This autologous cell therapy marketed by Dendreon has been approved for castration resistant prostate cancer
What is Provenge?
200
A heterogeneous group of solid malignancies derived from bone, cartilage, fat, muscle and vascular tissue
What are sarcomas?
300
Pfizer’s Xalkori is indicated for lung cancers with translocations affecting this gene
What is ALK1?
300
In this type of bone marrow transplant, patients receive hematopoietic stem cells from other individuals
What is allogeneic?
300
Abbreviated FISH, this technique is used to detect specific DNA sequences in tumor tissue sections
What is fluorescence in situ hybridization?
300
This presence of this marker is being evaluated as means of predicting responses to drugs targeting PD-1
What is PD-L1 (or PD-1 ligand)?
300
Pfizer’s small molecule, anti-angiogenic tyrosine kinase inhibitor approved for renal cell carcinoma and hepatocellular carcinoma
What is Sutent (or sunitinib)?
400
Gleevec is indicated in cases of CML with this chromosomal defect
What is BCR-ABL fusion or the Philadelphia chromosome?
400
This abbreviation is used to describe acute leukemias that originates from the myeloid hematopoietic lineage
What is AML?
400
The abbreviation LDT is used to describe these types of tests that are commonly used by molecular labs but that are not FDA approved
What are laboratory developed or home brew tests?
400
The first BMS agent developed for cancer that targets T cell activation checkpoint control
What is Yervoy (or ipilimumab)?
400
The lymph nodes closest to a tumor that are biopsied for metastasis
What is sentinel?
500
This is the most common BRAF mutation identified in malignant melanomas
What is V600E?
500
Sezary syndrome is a manifestation of this type of lymphoma
What is CTCL or cutaneous T cell lymphoma?
500
Abbreviated ASR, these products are used by labs in the design and validation of LDTs
What are analyte-specific reagents?
500
Abbreviated CARTs, these engineered autologous cells are being evaluated as therapy for hematologic cancers by Juno Therapeutics and other biotech companies
What are chimeric antigen receptor T cells?
500
An epithelial cell type commonly affected in various types of carcinoma