Clinical Trial File
This high-profile phase III trial evaluated the addition of the immunotherapy drug durvalumab (Imfinzi) to standard FLOT chemotherapy before and after surgery for patients with resectable gastric and gastroesophageal junction cancers. Its name is shared with a famous, jagged peak in the Alps.
What is the MATTERHORN trial
The correct pronunciation of this word: Nucleus.
What is Noo CLEE us.
This blockbuster antibody-drug conjugate targeting HER2 (famous for its success in breast and lung cancers) carries a prominent boxed warning for causing a rare, life-threatening autoimmune-like interstitial lung disease (ILD) or pneumonitis
What is fam-trastuzumab deruxtecan
What is the max volume per syringe of luspatercept?
1.2 mL
Who is Cindy Crawford or Kaia Gerber
This trial showed efficacy for Enhertu for HER2-low metastatic breast cancer.
What is the DESTINY-Breast04 trial.
This is the taxane toxicity caused by narrowing of the tear duct, resulting in excessive tear formation.
What is epiphora.
This B-cell maturation antigen (BCMA)-targeted antibody-drug conjugate, used for multiple myeloma, carries a mandatory safety program (REMS) because its toxic payload accumulates in the eyes, causing microcyst-like changes in the corneal epithelium known as keratopathy.
What is belantamab mafodotin.
These maintain a closed pressure equalization that prevent the escape of vapor and aerosols during compounding and administration.
What are Equashield Syringe Units.
What is Zach Zawacki's favorite food?
What are mashed potatoes.
This highly discussed international phase III trial pooled data from over 12,000 patients to see if 3 months of adjuvant FOLFOX or CAPOX chemotherapy was just as good as 6 months for stage III colon cancer.
What is the IDEA trial or IDEA collaboration.
Abnormal, needle-shaped crystalline inclusions found in the cytoplasm of leukemic blasts most frequently seen in APL.
What are Auer rods.
Name two oral agents that can induce differentiation syndrome. They must be from different drug classes.
Ivosidinib, enasidinib, ATRA
A patient reacts to paclitaxel bag and is sent to the ER. A 750 mg carboplatin that is already made will need to be repurposed and used for a 600 mg dose. This volume of drug solution should be removed from the bag and replaced with an equal volume of D5W.
Remove 68 mL and replace with 68 mL D5W
What notes are played here?
What are (answers on the website)
First published in late 2021, this monumental phase III trial permanently transformed the treatment of early-stage triple-negative breast cancer (TNBC) by showing that adding pembrolizumab to neoadjuvant chemotherapy, and continuing it adjuvantly, significantly improved event-free survival.
What is the KEYNOTE-522 trial.
Seen in aggressive leukemias and lymphomas, this oncologic emergency occurs when a massive burden of white blood cells plugs the microvasculature, causing tissue ischemia, respiratory failure, or intracranial hemorrhage.
What is leukostasis.
On average - this oral lung cancer agent causes nearly 30% increase in serum creatinine which is transient and not representative of true kidney damage.
What is tepotinib.
old-school: What was the unique method to take zoomed photos when PK first started?
Reading glasses or magnifying glassed fixed onto tablets in front of the camera.
Aimee's license plate (and meaning)
ADRC - Aimee Danette Ruder Cloud
Presented as a major practice-changing study at ASCO 2024, this phase III trial showed that using the third-generation EGFR inhibitor osimertinib as consolidation therapy dramatically prolonged progression-free survival in patients with unresectable, stage III EGFR-mutated NSCLC whose disease had not progressed after chemoradiotherapy.
What is the LAURA trial.
This lab abnormality, fasly appearing dangerously high, occurs due to the fragility of leukemic white blood cells, which break down (lysis) during the blood clotting process or sample centrifugation, releasing their intracellular potassium.
pseudohyperkalemia
One antidote for this toxicity is methylene blue. Name the drug and the toxicity.
Ifosfamide-induced encephalopathy.
Name two meds (including one pediatric product) that require a double dilution to make certain doses (not desensitizations).
The recipients (in reverse chronological order) for the Oncology Pharmacy Excellence Award for the last 5 years.
Chelsea Palmer, Barb Ostrowski, Colton Zwart, Amanda Kogelman, Katherine Finfrock