Hell on Earth
What's in that flask?
It's a wonderful RNA world.
Name that old white guy.
Protocell Pathway
100

Approximately how many years ago did Earth's history begin with its formation?

4.6 billion years ago.

100
In 1859, Louis Pasteur invented this flask that allowed air to get in but not microorganisms. 

Swan-necked flask. 

100

What does RNA stand for?

Ribonucleic Acid 

100

These two scientists made a groundbreaking discovery that showed amino acids (and other biomolecules) could be synthesized from inorganic material. 

Stanley Miller and Harold Urey
100

What is the name for the earliest model of a cell?

Protocell

200

Where is it believed that life first began on Earth?

In the oceans, near hydrothermal vents.

200

Describe the experimental setup and results for the 3 jars in Redi's experiment. 

Jar 1 - Meat covered with cork/paper = no maggots inside or outside

Jar 2- Meat covered with gauze - maggots grew on top of gauze, none on the meat inside. 

Jar 3- Meat uncovered - maggots grew on meat inside. 

200

What is the name of the RNA molecule that can catalyze chemical reactions, similar to a protein enzyme. 

Ribozyme

200

Who was the first to coin the term "spontaneous generation"?

Greek philosopher, Aristotle. 
200

These two scientists who lived in separate countries independently proposed similar ideas about the conditions that may have led to the origin of life on Earth. 

Russian scientsit Aleksandr Oparin 

English scientist John Burdon Sanderson  (J. B. S) Haldane 

300

What two things are required for the essential elements and compounds on early Earth to react?

Water and energy. 
300

Pasteur set out to design a flask based on criticism from Spallanzani's experiment. What did critics claim about Spallanzani's design?

Critics said that boiling the broth too long had destroyed the invisible "life force" in the broth. They said that cool fresh air was needed to supply the necessary magic life force. 

300

Why did DNA later replace RNA as the molecule to store information?

It is more stable due to: 

The deoxyribose in the DNA sugar-phosphate backbone makes DNA chemically more stable.

The hydrogen bonds holding together the double-helical structure of DNA add additional stability.  

Use of thymine rather than uracil further enhances DNA stability.  

300

The results of these two scientists contracticted each other.  

Spallanzani and Needham 

300

What are the three different types of membranes? 

Vesicle 

Micelle

Bilayer 

400

Prebiotic Earth experienced high levels of UV radiation, why?

It lacked a significant amount of oxygen in its atmosphere, which is necessary for the formation of ozone, the protective layer that shields the planet from harmful UV rays.

400
The Miller-Urey experiment utilized several compartments and equipment. Name the four key components of their design

The oceanic compartment

The atmospheric compartment 

Condenser 

Electrode 

400

What is the name of the idea that in the early stages of life on Earth, RNA molecules were the primary carriers of genetic information and performed catalytic functions,

The RNA World Hypothesis 

400

What is the full name of the scientist who developed modern germ theory. 

Louis Pasteur 

400

What are the 4 steps of the Oparin-Haldane hypothesis? 

1) Synthesis of simple organic molecules from inorganic compounds. 

2) Polymerization 

3) Self-replicate 

4) Creation of a protocell through packaging with a membrane. 

500

Name the 5 gases present on prebiotic Earth WITH their chemical formulas. 

Methane - CH4

Carbon Dioxide CO2

Nitrogen N2

Hydrogren H2

Ammonia NH3 

500

John Needham's experiments on spontaneous generation had several flaws. List 3.

  • Boiling time: Needham's boiling time was not long enough to kill all microbes. 
  • Open flasks: Needham left his flasks open while they cooled, which allowed for microbial contamination from the air. 
  • Sterile technique: Needham did not use proper sterile technique because he transferred the boiled broth into another flask that was not sterilized. 


500

Why is RNA and not DNA thought to have given rise to life?

Catalytic ability:Unlike DNA, RNA molecules (called ribozymes) can fold into complex shapes allowing them to catalyze chemical reactions, which is crucial for life processes. 

Simpler structure:RNA is chemically simpler than DNA, making it more likely to have formed spontaneously under early Earth conditions. 

Evolutionary evidence: Some modern biological processes still rely heavily on RNA, like the ribosome (the protein-building machinery) which is largely composed of ribosomal RNA.


500

These two gentlemen together disproved the theory of spontaneous generation for both macroscopic and microscopic organisms. 

Francesco Redi 

Louis Pasteur 

500

What is the Murchison meteorite and why is it significant in the quest for the origin of life?

In 1969, the Murchison meteorite smashed into Australia. One of the oldest known remnants of the pre-Earth solar system, this meteorite played a pivotal role in confirming the presence of carbon molecules elsewhere in the universe.

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