Let's Talk About FRAX, Baby!
It was developed to estimate the 10-year fracture risk for a given patient.
What is the FRAX tool?
This has already occurred by the age of 19 in females.
What is peak bone mass?
The age recommended to begin screening for osteoporosis in women, if no risk factors exist.
What is 65 years old?
These are the four bisphosphonates approved for treatment of osteoporosis.
What are alendronate, risedronate, ibandronate, and zoledronic acid?
This class of medications should not be prescribed after denosumab due to loss of BMD at the hip.
What are PTH analogs (abaloperitide, teriperitide)?
This behavior is a risk factor for osteoporosis and can also cause many types of cancer.
What is smoking?
Presence of this should prompt treatment for osteoporosis despite normal bone mineral density.
What is a fragility fracture?
This is the only test that has been validated to diagnose osteoporosis.
What is a DEXA scan? (Or bone densitometry)
This is the only estrogen agonist/antagonist approved for the prevention and treatment of osteoporosis.
What is raloxifene?
Using this class of medications first will decrease the effectiveness of further osteoporosis treatment.
What is bisphosphonate therapy?
Treatment for osteoporosis should be considered when this is 20% in the next 10 years.
What is risk of major osteoporotic fracture?
Mortality within one year of a hip fracture is this.
What is 20%?
This is the BMD (bone mineral density) measurement of the patient compared to a young, healthy cohort and is used to diagnose osteoporosis in postmenopausal women.
What is the T-score?
This sclerostin monoclonal antibody is most effective at reducing fracture risk as the spine.
What is romozosumab?
This medication should not be prescribed if the patient has had a heart attack or stroke within the last year.
What is romozosumab?
This autoimmune disease increases your risk for osteoporosis.
What is rheumatoid arthritis?
This study showed that screening for osteoporosis using fracture prediction models reduces hip fractures by 8,000 annually and is cost effective.
What is the SCOOP screening strategy?
This is the BMD (bone mineral density) of a patient compared with the BMD of women her own age.
What is the Z-score?
Recombinant human parathyroid hormone 1-34.
What is teriparatide?
This technology shows the quality of bones better than merely measuring bone density alone.
What is trabecular bone score?
Treatment for osteoporosis should be considered when this is 3% over the next 10 years.
What is risk of hip fracture?
These are markers of bone formation and bone resorption, respectively.
What are propeptide of type I procollagen (PINP) and the carboxy-terminal telopeptide of type I collage (CTX-I)?
The range of T-score for osteopenia.
What is <-1.0 to >-2.5?
A RANK ligand inhibitor used to treat osteoporosis especially in women with high risk of fracture.
What is denosumab?
These three studies demonstrate that optimal use of current osteoporosis medication is sequential treatment, starting with a bone building, followed by an antiresorptive drug.
What are the ACTIVExtend, FRAME and ARCH studies?