How do I know I have it?
The name of the screening for ovarian cancer
PAP SMEAR
The surgery types
TAH - BSO
Oophorectomy
Maintenance therapy for PARP-1
OLAPARIB
RUCAPARIB
NIRAPARIB
Early satiety and vaginal bleeding
Taxane / platinum
What is is the cycle for each stage?
Stage 1: 2-4
Stage 2: 4-6
Stage 3: 4-6
Stage 4: 6-8
Labs
Biopsy
CA125(< 35 is normal) and CA19-9
LFT
If they are platinum sensitive meaning
> 6 months and you can use the same regimen
do the tx change in ovarian cancer
no
How bad is it?
stage 1,2,3,4
If they are platium resistance meaning?
less than 6 months and you cannot use the same regimen
change to DOXI
What are the side effects of the PARP-1 inhibitors
Anemia, Thrombocytopenia and Neutropenia
What are the goals of therapy?
stage 1 and 2 = cure
stage 3 and 4 = pallative
Maintenance therapy for Ovarian Cancer
Bevacizumab (IV)
What is the side effect for bevacizumab
bleeding, HTN, proteinuria, VTE, delayed wound healing