Somebody call benign-1-1, shawty fire burning down the dance floor(cancer)
Your skin, oh yeah, your skin and bones. Turn into something beautiful.(integumentary)
Hello from the other siiiiide, I could contract a thousand tiiimes(skeletal muscle)
It means no worries for the rest of your days. It's our problem free, muscular dystrophy.. Hakuna Matata.
You are the dancing queen, young and sweet only 17 pathologies
100

what type of tumor grows quickly and can metastasize to other parts of the body

malignant

100

What are the five layers of the epidermis from outer to most inner

(stratum)corneum, lucidum, granulosum, spinosum, basale

100

Which ion is the stimulus for all muscle contraction and where is it stored in the muscle

Calcium

in the sarcoplasmic reticulum

100

What is a useful marker of muscular necrosis we see in patients with dystrophy

creatine kinase

100

What is the most prevalent bone disease

osteoporosis

200

With cancer patients there can be a distressing, persistent sense of tiredness not proportional to activity, this is called...

CRF, Cancer Related Fatigue

200

what type of cells in the skin function as immune antigen-presenting cells 

Langerhans cells

200

Which protein blocks the active binding sites on actin and which other protein is responsible for unblocking the site.

Tropomyosin blocks the binding site and troponin will change shape and pull tropomyosin off of the binding sites

200

What is the most common form of the muscular dystrophy and which protein is mutated to cause it

(DMD) Duchenne Muscular Dystrophy

dystrophin

200

With RA, the immune system mistakenly attacks the synovial membrane so we end up getting a thickened inflammed layer known as 

pannus

300

A patient with cancer is on long-term corticosteroids. Which adverse effect should the physical therapist monitor most closely?

Muscle weakness and skin fragility

300

What type of corpuscle in the skin responds to skin stretch

ruffini corpuscle 

300

What is the size principle of motor units


    • Motor units with smallest muscle fibers recruited first 
    • Motor units with larger and larger fibers recruited as stimulus intensity increases
    • Largest motor units activated only for most powerful contractions
300

Name and briefly describe an acquired myopathy

  •     ◼Hyperthyroidism: high metabolic rate leading to reduced nutrient stores for muscles to utilze  muscle weakness
  •     ◼Diabetic myopathy
    • Chronic hypoperfusion of muscle (vascular component)
    • Degeneration of peripheral nerves (neurogenic component)
    • Disturbances of carbohydrate metabolism (metabolic component)

  •     ◼Cancer myopathy
    • Common paraneoplastic syndrome
    • Often related to antibodies to tumors cross-reacting with autoantigens in muscle and skin (dermatomyositis)
    • Causes immune-mediated inflammation in muscles
300

Staging for malignant melanomas is based on what

Depth of dermal infiltration

400

Gait and balance training emphasizing visual input would be beneficial for patients with this chemo related issue

chemotherapy-induced peripheral neuropathy

400

What three pathologies make up the atopic triad 

eczema, allergic rhinitis, asthma

400

Name two places where ATP is used in the muscle contraction/relaxation process

ATP binds to the myosin head and it is broken down to release energy and cause a powerstroke. 

ATP is used to pump calcium back into the SR during relaxation

400

What is the most common cause of peripheral neuropathy and where do the symptoms first present

Diabetes

Stocking glove presentation(hands and feet)

400

What is the first line therapy for pain management of OA?

Acetaminophen

500

What might a patient be prescribed if they have cancer related bone pain in order to reduce risk of fractures and decrease that pain

Bisphosphonates 

500

Which bacteria is typically the most common for a skin infection

Staphylococcus aureus

500

What type of proteins mediate the fusion of neurotransmitter vesicles to the pre-synaptic membrane

SNARE proteins

500

Neurotropism like we see in polio is when..

Virus targets motor neurons in the spinal cord or brainstem

500

Methotrexate is in what drug class and is first line treatment for what disorder

DMARDs and rheumatoid arthritis

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