Preventive Neurology
The number of people expected to be affected by dementia by 2050?
131 million
The name of the three biomarkers being utilized to identify someone in the Alzheimers spectrum
Amyloid, Tau, and NFL
This is how you initate the Brain Health program
Send a clinical case in Athena
The first presenting symptom of AD or amnestic MCI is typically this
Short term recall
Dementia related costs in the US are estimated to be this
200 billion
One copy of APOE4 increases dementia risk by this, two copies increases risk of dementia by this
4 and 8
Prior to the second visit the member will receive
Long term memory
This percentage of patients with mild cognitive impairment who will progress to dementia annually
10-15%
The number of modifiable risk factors based on recent Lancet report
14
tau- specifically p217
The first visit involves this
A very detailed history of childhood, education, and any risk factors or exposure that suggest higher risk of AD
People with AD may develop loss of sense of smell called this
Anosmia
amyloid plaque and tau neuritic plaque
The primary motivator for patients to seek risk reduction management
Family history of dementia
APOE4 has an increase in this lipid/lipoportein level and therefore cardiovascular risk
LDL-C and ApoB
The cognitive testing involves
NIH toolbox, Neurocatch, etc
Visual symptoms including the ability to recognize faces or process visual information are common presenting symptoms in this variant
Posterior Cortical Atrophy
AD typically involves shrinkage of this area of the brain which is known to control memory
Hippocampus
The ABCs of preventive dementia include this
Anthropmetrics, Blood biomarkers, Cognition
Plasma Ab levels are present ____ less in the serum than in the CSF
20-40 times
The final visit involves
Feedback session with formal report, can be done in person or virtually
The inability to find the right word , repeat or comprehend
aphasia
PET amyloids can be abnormal in normal patients
True