Endocrine or Neurologic
Anti-VGCC antibodies leading to decreased acetylcholine release results in autonomic dysfunction and proximal muscle weakness in this syndrome, commonly seen in patients with SCLC
Lambert-Eaton myasthenic syndrome
The sterile vegetations in NBTE are composed primarily of these two materials.
Fibrin + Platelets
What is the patient's age?
49 years old
Paraneoplastic encephalomyelitis and sensory neuronopathy is another way to describe this syndrome that is characterized by autoantibodies that target neuronal proteins
Anti-Hu syndrome
This descriptor, starting with F, is typically used for the texture of NBTE vegetations or for caseous necrosis
Friable ("crumbly like cheese" - Joey)
What is the patient's name?
Allegra Johnson
Hypercalcemia in squamous cell carcinoma of the lung is due to secretion of this peptide.
PTHrP. Parathyroid Hormone-related protein.
Which imaging modality is best suited for detecting NBTE?
Bonus: On which valves do vegetations tend to collect?
Echocardiogram, TEE > TTE
Bonus: Aortic + Mitral
What is the patient's tobacco usage?
1 ppd for 30 years
Ectopic ACTH and SIADH secretions are paraneoplastic phenomena that commonly occur with which malignancy?
Small cell Lung Carcinoma
Trousseau's Syndrome is often seen with adenocarcinomas. Name two or more adenocarcinomas classically associated with Trousseau's.
Pancreatic, Lung, Gastric, Ovarian
What is the patient's past surgical history?
Tubal Ligation
Name 3 paraneoplastic syndromes associated with thymomas
Pure Red Cell Aplasia, Good syndrome, and Myasthenia Gravis
Describe the proposed mechanism for Trousseau's Syndrome
tumor secretion of mucins and tissue factor activate widespread coagulation elements
What does the patient do for work?
Bookkeeper for her husband's company