Parkinsons Jeopardy

Neurons

100

The lack of this neurotransmitter is the main cause of symptoms in PD

Dopamine

200

These aggregate in neurons, and are a hallmark pathology of not just Parkinson's, but other Neurodegenerative diseases as well.

Lewy Bodies

300

These two characteristics predispose A9 neurons to be greatly affected by mitochondrial damage to the cell

Large size and lack of myelination

Genes

100

This gene encodes for alpha synuclein

SNCA

200

This gene is mutated in 5-14% of PD cases, making it the most common genetic risk factor

GBA

300

This recently discovered PD-associated gene accounts for over 90% of all parkinson's cases

Trick Question! There is no single gene that is the main cause of parkinson's

The names of Parkinsons

100

He was the first to describe Parkinson's disease

James Parkinson

200

This famous actor died after a misdiagnosis of Parkinsons

Robin Williams

300

This scientist further classified PD after James Parkinson

Jean-Martin Charcot

Primary Literature

100

This type of Macropage resides within the CNS

Border-associated macrophage (BAM)

200

This cell type was originally thought to be the sole cause of neuroinflammation in PD.

Microglia

300

This type of treatment was used to deplete macrophages in murine models

  Clodronate filled liposomes (CL)

Numbers, Numbers, Numbers!

100

This class of MHC receptor is expressed on macrophages and is responsible for activating T helper cells, cells that cause neuroinflammation

2

200

This is the number of different stages of PD Braak defined

6

300

This was the year that "shanking palsey" was first described by parkinson

1817