in general
What is one way that the adaptive immune system is differentiated from the innate immune system?
- specificity
- memory
- evolves with each subsequent infection
In what kind of cells does sirolimus inhibit the cell-cycle?
all rapidly dividing cells
What 1985 song by Kate Bush made a significant resurgence after being featured in Stranger Things Season 4?
"Running Up That Hill"
Which condition affecting hair growth is an adverse effect of cyclosporine?
hirsutism
T/F: The average half-life of everolimus is 62 hours.
F, it is 20 hours
What are the two major arms of the adaptive immune system?
1) humoral arm
2) cell-mediated arm
T/F: IL-2 receptor antagonists are one of the only treatment options for transplant rejections.
F, they do NOT treat transplant rejection
What is the original use of Play-Doh?
Wallpaper cleaner
Which condition affecting hair growth is an adverse effect of tacrolimus?
alopecia
What is the only patient population that belatacept is indicated for?
kidney transplant patients
What is the primary function of B cells?
antigen recognition and production of antibodies---humoral immunity
What is prednisone a substrate of?
CYP3A4
What is the collective noun for a group of jellyfish?
Smack
What is an adverse effect of mycophenolate that is dependent on dose?
- nausea
- diarrhea
- lymphopenia, thrombocytopenia
What does azathioprine get converted into?
6-mercaptopurine
Which major subgroup of T cells induce inflammation?
T memory cells (CD4+ or CD8+) (delayed hypersensitivity cell)
In cyclosporine's MOA, what does CSA form a complex with?
cyclophilin
Which city lies on two continents?
Istanbul
What category of medications have the following possible adverse effects: hyperglycemia, osteoporosis, weight gain, impaired wound healing and fluid retention? Hint: another adverse effect is cushingoid state
corticosteroids (glucocorticoids also acceptable answer, but corticosteroids is more correct)
When would a patient never start sirolimus and why?
just after transplant surgery due to the adverse effect of poor wound healing
What is the third signal needed for T cell activation?
interaction of IL-2 with IL-2 receptor
What is the only agent that wipes out cells in innate and adaptive immune system?
alemtuzumab (anti-CD52)
What dessert translates to "pick me up" in Italian?
Tiramisu
What is the incidence of leukopenia for azathioprine?
>50%
What is the name (not acronym) of the enzyme mycophenolate is an inhibitor of?
inosine monophosphate dehydrogenase (IMPDH)