Frett 41-42
___________ selective agonists can be used in the treatment of myasthenia gravis.
Nicotinic
Scopolamine, Homatropine, and Atropine are all muscarinic antagonists in what group?
The Nightshade Alkaloids
What type of AChE inhibitors exhibit toxic effects?
irreversible
Neuromuscular blockers prevent ACh from binding to _________ receptors at the neuromuscular junction.
nicotinic
T/F: The circulatory system is more than 60,000 miles long
T
What indication is cevimeline FDA approved for?
Sjogren's syndrome (dry mouth)
Name one muscarinic antagonist from the group of amino alcohols and ethers.
Trihexyphenidyl, orphenadrine, benztropine
__________ based inhibitors slow down the rate of regeneration from a fraction of a msec to minutes, thus the AChE enzyme is inhibited for a much longer period.
Carbamate
What type of neuromuscular blocking agent has a fast onset and short duration?
partial agonist
In what country was the world's first animated feature film made?
Argentina
Name at least one condition that muscarinic selective agonists can be used in the treatment of.
1) glaucoma and pupil dilation
2) switching on GIT and urinary tract after surgery
3) certain heart defects- decreases heart muscle activity and decreases heart rate
Which muscarinic antagonist in the group of quaternary alcohol esters is used as a preoperative to inhibit salivary and respiratory secretions?
Glycopyrrolate bromide
____________ inhibitors usually resemble ACh in structure.
Reversible
What is first affected with loss of control voluntary muscles?
muscles associated with rapid movement (ex: face, eyes, neck, etc)
Which famous cookie maker was also a talent rep for Diana Ross, Sam Cooke, and Marvin Gaye on top of being responsible for discovering and signing Simon & Garfunkel?
Wally Amos
Which enzyme catalyzes the synthesis of acetylcholine from choline and acetyl-CoA?
Choline acetyltransferase
Which group of muscarinic antagonists contain drugs used to treat COPD?
Quaternary tropium based
Is pyridostigmine bromide or neostigmine a better choice for oral therapy of myasthenia gravis?
Pyridostigmine bromide
What type of neuromuscular blocking agent has a slow onset and long duration?
competitive antagonist
From what country was the first person processed at Ellis Island from?
Ireland
What selectivity would an acetylcholine methylated at beta position display?
Muscarinic
Which two tertiary amino esters are used to treat overactive bladder?
Oxybutynin and Flavoxate
Donepezil has a greater affinity for AChE in the _____ than for cholinesterases in the periphery.
brain
How many molecules of ACh are required to activate the ion-channel?
2
In an attempt to offer healthier options, McDonalds once tested bubblegum flavored ____________.
broccoli