Receptors
Binding of this adrenergic receptor by dobutamine treats septic shock by increasing inotropic effect
What is B1?
Mechanism by which cromolyn sodium and nedocromil prevent histamine release
What is inhibition of mast cell degranulation?
What is deferoxamine?
2 potential side effects of bradykinin accumulation associated with taking Lisinopril, an ACE inhibitor
What are dry cough and angioedema?
Phase of clinical trials that involves patient-subjects and tests drug efficacy and dose-ranging
Specificity for this receptor allows Tamsulosin to treat BPH without the side effect of orthostatic hypotension
What is A1a?
Levels increased in the corpora cavernosa by Sildenafil, a PDE5 inhibitor that treats erectile dysfunction
What is cGMP?
Depolarizing paralytic agent in surgery that agonizes Nm receptors and is not metabolized by AChE
PGE2 analog acting on uterine smooth muscle that relaxes the cervix during labor
What is dinoprostone?
Controlled substance schedule that requires a written prescription, and exam by MD before refill, and that providers must keep in a secured area
What is schedule II?
A 30 year old complains of an onset of xerostomia, dry throat, and dryness of the eyes. He also complains of joint pains in his knees and elbows as well as swelling in his finger and toe knuckles. He was later diagnosed with Sjogren's syndrome and given medication to combat his symptoms. Name the receptor that this medication acts on.
What are M3 receptors?
Effect on intracellular Ca+2 levels when Bethanechol, an M3 agonist, is administered to treat atonic bladder
What is increase?
PGE1 analog administered to an infant with congenital cyanotic heart disease being prepared for surgery to maintain patency of the ductus arteriosus
What is Alprostadil?
AChE inhibitor that treats glaucoma, atropine toxicity, and is administered carefully to soldiers in anticipation of nerve gas exposure
What is physostigmine?
The 2 goals of conjugation by glucuronidation in the endoplasmic reticulum
What are drug inactivation and water solubility?
Binding by Fenoldopam causes renal, coronary, and mesenteric vasodilation during a hypertensive emergency
What is D1?
A new patient presents with gastric ulcers and GERD. They tell you that the pain is worse after eating meals and when laying down. You decide to prescribe a drug to manage symptoms. A few days later, the patient complains of blood in the urine and has coughed up blood for the past few mornings. You ask the patient a few more clarifying questions and discover that the patient has a history of blood clots and was prescribed warfarin at their primary clinic. They have been on this drug for the past two years without complications. Name the drug you prescribed to the patient that has caused the bleeding and why the complication occurred.
What is cimetidine due to inhibition of CYP3A4?
2 second generation H1 antihistamines that reduce PKC activity and do not cross the blood brain barrier and
What are Certirizine and Mepyramine?
Condition treated by Ranitidine, an H2 antihistamine that reduces cAMP in gastric mucosa, cardiac muscle, mast cells, and the brain
What are stomach ulcers?
95% of an orally-administered dose of a drug is detected in systemic circulation. This type of metabolism by CYPs has a minimal effect on this drug's absorption.
What is hepatic first pass metabolism?
Receptor blocked by Phentolamine to reverse the effects of an accidental EPI injection at the fingertip
What is alpha 1?
Effect on MLC by binding of NO to guanylyl cyclase when sodium nitroprusside is administered in a hypertensive emergency
What is dephosphorylation?
Hypertensive agent and adrenergic agonist that decreases sympathetic outflow
Non-selective B-blocker that treats HTN and angina but is contraindicated in asthmatics
What is propranolol?
Aspirin pKa is 3.5. In the stomach, pH = 1. The ______ form of aspirin prevails, favoring ________.
What are uncharged/permeable and absorption?