Mercury 1
How long was the washout period for patients using a prostaglandin analog or beta-blocker prior to study entry
4 weeks
How long was mercury 2?
3 months
Prostaglandins primary MOA?
Uveoscleral outflow
Rocklatan 4 major side effects with percentage?
Hypermeia 59%
Instilaation site pain 20%
Hemorrhage 11%
Verticillata 15%
What is my favorite color?
Red
When was mean IOP measured?
Time of day
week/month
Time: 8,10 and 4
Week/month: Week 2 and 6
Month 3,8,9,12
% of patients by month 3 with mean Diurnal IOP <= 18 mmHg
Rocklatan
79%
Main PGA side effects (5)
Eyelash growth
Periocular hyperpigmentation
Hyperemia
Iris color change
Periobital fat changes
The dosage form and strength of Rocklatan contains ____ mg/ml netarsudil and _____ mg/ml latantoprost
.02% N and .005% L
MOA for Alpha Agonists?
Aqueous suppression and Uveocleral outflow
The reductions in IOP were ________ mmHg with netarsudil/latanoprost FDC than with either netarsudil or latanoprost at all time points over 3 monts
1-3
% of patients by month 3 with mean Diurnal IOP <= 16 mmHg
Rocklatan
58%
Primary MOA
Trabecular meshwork outflow
Lumigan's most common adverse reaction is? What percentage?
Hyperemia 31%
How many patients in the us have been diagnosed with glaucoma
Over 3 million
What percent of patients with reduced mean diurnal IOPs to 16 mmHg or lower?
And what percent of
Rhopressa and Latanoprost
60%
Rhopressa 37%
Latanoprost 35%
% of patients by month 3 with mean Diurnal IOP <= 14 mmHg
Rocklatan
32%
Hyperemia
Verticillata
Hemorrhage
Which PGA's hyperemia is is 30%-50%
Travatan Z
How would you position Rocklatan
Switch before adding PGA
1st-line therapy
How many time points did Rocklatan show superiority over netarsudil and Latanoprost?
18
% of patients with hyperemia
58%
Rho Kinase contraindications
NONE
Generic name for Lumigan, Vyzulta, and Travatan Z
L- Bimatoprost
V- Latanoprosten bunod opthalmic solution
T- Travoprost
5 key selling message of Rhopressa
1. Up to a mean 5 point reduction (Efficacy)
2. Minimal to no systemic side effects
3. once a day dosing
4.MOA
5. It's in the refrigerator