Hormonal Hotline
This hormone is secreted from the hypothalamus in response to stressful stimuli.
What is corticotropin-releasing hormone (CRH) (1)?
This class of medication is the most effective for arachidonic acid cascade inhibition.
What are corticosteroids? (3)
Mifepristone performs this mechanism to treat hyperglycemia due to high levels of cortisol
What is glucocorticoid receptor inhibition? (3,6)
A patient presenting with moon facies, obesity and a buffalo hump likely has this condition.
What is Cushing’s Syndrome? (8)
CRH will act on receptors in this area.
What is the anterior pituitary? (11)
This anterior pituitary hormone stimulates cortisol production in the adrenal cortex.
What is adrenocorticotropic hormone (ACTH) (1)?
This drug is commonly used to reduce hyperglycemia in Cushing’s syndrome.
What is Mifepristone? (3)
Bromocriptine is used to manage Parkinson’s Disease by binding to dopamine D2 receptors in order to reverse this disease complication.
What is degeneration of dopaminergic neurons? (7)
Name 4 symptoms associated with Addison’s disease.
What are fatigue, dehydration, weight loss, hypoglycemia, water-electrolyte imbalances, renal dysfunction, GI disturbances, weakness (9)
These receptors responds to the presence cortisol to increase blood glucose
What are glucocorticoid receptors? (11)
This hormone is likely low if Luke’s blood test reveals high levels of ACTH.
What is cortisol (1)?
These are the two most common drug targets in the arachidonic acid cascade.
What is phospholipases and cyclooxygenase? (5)
Ketoconazole is used to in palliative treatment of Cushing’s syndrome by inhibiting steroid synthesis at high doses by these two mechanisms.
What is inhibition of cholesterol (precursor to steroids) side-chain cleavage and inhibition of P450 enzymes? (3)
Diagnostic testing for this condition reveals higher than normal cortisol, but low ACTH
What is Cushing’s syndrome caused by an adrenal tumor? (8)
This receptor subtype has a much higher affinity for cortisol.
What is the mineral corticoid receptor? (12)
A high level of this hormone would cause Sally presents with weight gain, moon facies, and hypertension, what is the hormonal cause of this?
What is hypercortisolism (1)?
These four medications inhibit the cyclooxygenase enzyme, reducing the production of prostaglandin.
What is aspirin, ibuprofen, naproxen, and celecoxib? (5)
Spironolactone can treat hirsutism and acne in women by decreasing aldosterone’s peripheral effect via this mechanism
What is aldosterone receptor inhibition? (3)
This condition has an autoimmune cause resulting in destruction of the adrenal cortex.
What is primary adrenal insufficiency (Addison’s)? (9)
This enzyme inactivates cortisol by oxidizing the OH at C11 to make cortisone.
What is 11 beta-dehydrogenase? (13)
Kerry has elevated cortisol levels. He is treated with dexamethasone which suppresses the secretion of ACTH. However his cortisol levels remain high. This site in the HPA axis is likely the problem.
What is the adrenal gland (2,3)?
This corticosteroid is used in combination with hydrocortisone for patients with Addison’s Syndrome because
What is fludrocortisone because its high mineralocorticoid activity replaces the lost aldosterone activity? (3)
Aminoglutethimide is used in combination therapies to eliminate estrogen production in breast cancer patients by this mechanism.
What is blocking the conversion of cholesterol to pregnenolone? (3)
Gina comes in with test results indicating low cortisol levels, symptoms of fatigue and skin hyperpigmentation caused by this disease.
What is ACTH deficiency? (9,10)
This receptor responds to ACTH stimulation in the adrenal cortex.
What is the melanocortin 2 receptor? (3)