Don't Act The Fool
You could be a model (system)
Rock, Paper, Scissors
Graveyard Shift
Nothing Rhymes with Phagocytosis
100
An actin filament has a plus end and a minus end, which is said to give them this.
What is polarity (or directionality)?
100
Picture Jeopardy! The tissue found in this picture shows this condition in which an artery wall thickens as a result of the accumulation of debris and cholesterol.
What is an athersclerotic lesion/plaque?
100
The members of this protein family have been described as molecular switches, regulating many aspects of intracellular actin dynamics.
What is the Rho family of GTPases?
100
From the latin word efferre, this word means 'to take to the grave', 'to bury' and describes the process by which dying/dead cells (e.g. apoptotic or necrotic) are removed by phagocytic cells.
What is efferocytosis?
100
THIS is a phospholipid component, usually kept on the cytosolic side of cell membranes by an enzyme called flippase. During apoptosis, it becomes exposed on the surface of the cell and serves as an "EAT ME" signal for phagocytes.
What is Phosphatidylserine?
200
Picture Jeopardy! The subunits being added to the + end of a growing actin filament.
What are ATP-bound actin monomers?
200
When oxidized low-density lipoproteins LDL accumulate in macrophages and other phagocytes the cells are now known as THESE.
What are foam cells?
200
This kinase is mainly involved in regulating the shape and movement of cells by acting on the cytoskeleton.
What is ROCK?
200
Picture Jeopardy! This projection found on this moving cell.
What is a filopodia?
300
Double Jeopardy! A family of actin-binding proteins which disassembles actin filaments.
What is ADF/cofilin?
300
Cholesterol is transported in the bloodstream by THESE "protein suitcases" which are water-soluble.
What are lipoproteins (or LDL)?
300
A downstream target of Rho family proteins, this protein is a seven-subunit protein that plays a major role in the regulation of the actin cytoskeleton by acting as a branching nucleator?
What is Arp2/3 complex?
300
These fluorescent probes high selectivity for acidic organelles like lysosomes.
What is Lysotracker?
300
Picture Jeopardy! The 3D projection seen here.
What is pseudopodia?
400
Double Picture Jeopardy! The large, dynamic protein complexes through which the cytoskeleton of a cell connects to the extracellular matrix seen here.
What are focal adhesions?
400
Rapid efferocytosis in early lesions of atherosclerosis leads to blockage/suppression of THIS response.
What is proinflammatory?
400
These three common Rho family proteins regulate actin organization and cell adhesion in macrophages.
What are Rho, Rac and Cdc42?
400
Ingested apoptotic bodies are taken into THIS part of the macrophage, which is then fused to the lysosome.
What is a phagosome?
400
The phagocytosis of apoptotic cells blocks inflammation by inhibiting the production of these.
What are cytokines?
500
These proteins make up a large family of heterodimeric transmembrane glycoproteins that attach cells to extracellular matrix proteins of the basement membrane or to ligands on other cells. They also connect the extracellular matrix to the actin cytoskeleton.
What are integrins?
500
DOUBLE JEOPARDY! Apoptotic macrophages that accumulate eventually undergo secondary necrosis. The buildup of necrotic debris promotes inflammation, plaque rupture, and formation of THIS complication.
What is acute thrombosis?
500
Triple Picture Jeopardy! Rho-kinase inhibitor seen here.
What is fasudil?
500
In plaque rupture, the plaque inflammation erodes the fibrous lining to the point where it breaks apart, releasing necrotic debris which enhances the size of THIS.
What is the necrotic core?
500
Picture Jeopardy! The type of actin organization in the projection seen here
What is actin filament branching of the lamellipodia?
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