Besties
Who is abiraterone's bestie?
Prednisone!!! Used in combo to tx metastatic, castration-resistant prostate ca
olanzapine is structurally similar to what other drug? Hint: its difference is that olanzapine does not have agranulocytosis
clozapine
MAOIs / selegiline (happy patch)
Vincristine can injure what? Periwinkle plant!
Peripheral nerves
this drug causes osteonecrosis of the jaw
zonedronate/denosumab
Who is cyclophosphamide's bestie?
Mesna! Protective agent to the bladder
this SSRI and pregnancy do not get along (Cat D)
paroxetine (Paxil)... switch to fluoxetine (Prozac) or sertraline (Zoloft)
this benzo may cause cardiotoxicity and moderate orthostatic HoTN
amitriptiline
Fluorouracil toxicity
Palmar-plantar erythrodysthesia (hand-foot syndrome), neutropenia, oral and GI ulceration
this drug only works in ALL
aspariginase
Who is doxorubicin's bestie?
Dextrasone! Is a cardioprotectant.
Who is doxorubicin's enemy?
Trastuzumab (added with doxorubicin increase risk of cardiotoxicity)
this SSRI may improve sexual function
buproprion may IMPROVE sexual function, vortioxetine and vilazodone may be used for sexual dysfunction
Carmustine toxicity
Pulmonary fibrosis***, delayed bone marrow suppression, severe N/V
this drug has to be changed every 6 hours
propofol, mr. jackson.
Who is methotrexate's bestie?
Leucovorin. (When methotrexate is in high doses). Failure to admin leucovorin in the right time can be fatal.
Carbamazepine's enemy
Selegiline (happy patch)
Also avoid oxcarbazepine
this SSRI causes QT prolongation risk when given greater than 40 mg
citalopram
Cisplatin toxicity
Can injure kidneys, also ototoxic when extensive hydration occurs with diuretic therapy. Peripheral neuropathy and mild-moderate bone marrow suppression is also listed in there.
Most commonly occuring when combined with levodopa. dyskinesias, orthostatic HoTN, nausea, hallucinations
GI effects: yellow-orange urine
Who are paclitaxel's three besties?
Dexamethasone, benny, & ranitidine!! Used to premedicate
Tamoxifen's three enemies
Zoloft, paxil, and prozac
the antibiotic that causes serotonin syndrome
linezolid
Clozapine has a black box warning. What is it and what will you do
agranulocytosis: reduction in WBC and increaases risk of serious or fatal infection
soooo.... do a weekly CBC for 6 months, then 2 weeks. If WBC is decreased significantly (2000), stop immediately
Haloperidol has some unique drawbacks. can you name 3?
Extrapyramidal SE (EPS/pseudo-Parkinsonism), hyperprolactinemia, TARDIVE DYSKINESIA