This agent can be used for DVT prophylaxis in a patient with a calculated creatinine clearance of < 20 mL/min and can be reversed with protamine in a 1:100 ratio.
What is unfractionated heparin?
100
This is a selective alpha-2 agonist used for sedation in mechanically ventilated patients, procedural duration prior to/during awake fiberoptic intubation, and sedation prior to/during procedures of non-intubated patients.
What is dexmedetomidine (Precedex)?
100
A vasopressor with pure alpha 1 agonist activity.
What is phenylephrine?
100
Initial dosing (mg/kg) and frequency in a hemodynamically stable patient with a creatinine clearance > 55 mL/min.
What is 15-20 mg/kg Q 12 h?
100
Describes the measure of space in the body available to contain drug.
What is volume of distribution (Vd)?
200
Two independent risk factors for stress ulcer formation and therefore are indications for GI prophylaxis.
What is mechanical ventilation > 48 hours and coagulopathy (i.e. INR >1.5, PLT <50K)?
200
First line drug class for the treatment of NON-neuropathic pain in critically ill patients.
What are IV opioids?
200
Potential adverse effect of all vasopressors when administered peripherally that causes tissue necrosis.
What is extravasation?
200
Pharmacokinetic parameter (i.e. T>MIC) used to target clinical efficacy of vancomycin.
What is AUC/MIC?
200
The five components of pharmacokinetics (what body does to drug).
What is liberation, absorption, distribution, metabolism, elimination?
300
Creatinine clearance cutoff at which famotidine & ranitidine should be dose adjusted for renal dysfunction.
What is a creatinine clearance < 50 mL/min?
300
Sedation assessment tool used (in JHS SICU unit) for measuring quality and depth of sedation in adult ICU patients.
What is the Richmond Agitation Sedation Scale (RASS)?
300
In septic shock, pressor/dose that can be added to norepinephrine (NE) to raise the MAP or decrease NE usage.
What is vasopressin 0.03 units/minute?
300
Maximum single dose of vancomycin.
What is 2 grams/dose?
300
Diluent used in parenteral formulations of lorazepam and diazepam that can cause toxicity and manifests as metabolic acidosis and acute kidney injury.
What is propylene glycol?
400
Injectable anticoagulant that should be avoided in patients with a creatinine clearance < 15 mL/min, not FDA approved for use in hemodialysis, and has a half-life of six hours in patients with normal renal function.
What is enoxaparin (Lovenox)?
400
Class of medications that act on GABA receptors in the brain and have anxiolytic, amnestic, sedating, hypnotic, and anticonvulsant effects, but NO analgesic activity.
What are benzodiazepines?
400
In septic shock, this vasopressor that can be added to (potentially substituted) for NE when an additional agent is needed to maintain MAP.
What is epinephrine?
400
Creatinine clearance cutoff at which vancomycin dosing frequency must be adjusted.
What is < 50 mL/min?
400
Risk factors for this in the ICU include pre-existing dimentia, hypertension, alcoholism, and a high severity of illness on admission.
What is delirium?
500
The benefit of upper GI bleed prophylaxis should be weighed against these two potential adverse reactions. (Hint: specific two AEs mentioned during rounds)
What is C. difficile infection and ventilator-associated pneumonia?
500
One of the recommended first line sedative agents with sedative, hypnotic, anxiolytic, amnestic, antiemetic, and anticonvulsant properties, but NO analgesic effects; comes in a 1% lipid emulsion.
What is propofol?
500
In the SOAP II trial, this vasopressor was found to have an increase incidence of arrhythmias and mortality in patients with cardiogenic shock.
What is dopamine?
500
MIC at which an alternative to vancomycin should be considered due to higher potential of therapeutic failure.
What is MIC >/=2 ?
500
According to the Pain, Agitation, and Delirium guidelines, these pharmacological agent(s) (IF ANY) may be used to PREVENT ICU delirium in adults.