E, D, R
The transit of a drug from the central compartment to the peripheral compartment
What is drug distribution (k12)?
The three things we must know to estimate the plasma concentration of a drug at any given time
What is the summed impact of three individual reactions: distribution, redistribution, and elimination?
For a two compartment model the initial steep drop of the graph is dominated by this movement while the the more linear drop of the graph is dominated by this movement
What is distribution (k12) and then elimination (k10)?
The units for this variable are mass/volume
What is the units for plasma drug concentration (Cp) or steady state plasma drug concentration (Css)
The vessels that bring a drug away from the glomerulus
What is efferent arteries?
The compartment a drug must be in to be eliminated
What is the central compartment?
When redistribution (k21) is equal to distribution (k12) this dominates the movement of the drug
What is elimination?
If a VD is given in units of L and not L/kg it is based on this weight of a patient
What is 70 kg?
The units of this variable is inverse time for a first order elimination
What is the units for the elimination rate constant (k10)?
The three steps of renal elimination
What is glomerular filtration, proximal tubular secretion, and then distal tubular passive reabsorption?
Rounding out of a two compartment elimination curve represents
What is distribution (k12) and redistribution (k21) reaching equilibrium?
Areas of the body that have tight junctions preventing the passage even for small molecules
These factors control where a drug can distribute
What is its physico-chemical properties, affinity for plasma proteins, size, and blood flow?
The units of this variable are volume/time
What is the units for clearance?
The phase of metabolism that attaches larger, already-hydrophilic groups to the substrate
The three main methods of elimination the body can use
What is renal elimination, elimination via the small intestine, and chemical transformation of the drug to an inactive species (metabolism)?
The VD of a highly charged drug will be
What is about 5L?
The VD of a drug is 5L, what can be inferred about the drug's distribution pattern?
That the drug does not distribute appreciably into the peripheral compartment (stays in the plasma)
The units of this variable is concentration/time during a first-order elimination
What is elimination rate (re)?
What is glucuronidation?
The slope of a zero-order elimination curve
The CYP enzyme that is responsible for first-pass metabolism of many drugs
What is CYP3A4?
The time separating peak Cp and zero CP in a multiple bolus dosing model is known as the
Dosing interval (𝜏 )
The units of these variables are concentration/time for a zero order elimination
What are the units for elimination rate constant (k10) and elimination rate (re)?
The name of my fiance
What is Kiara?