cephalosporins
Cephalosporins cover enterococci? T/F
False
This cephalosporin covers MRSA, name drug and generation
5th generation
monobactam can be prescribed for truly PCN allergic patients: T/F?
True, there is no cross reactivity
avoid as a monotherapy for this bacteria
P. aeruginosa
name 4 beta lactam drug classes
Penicillins
cephalosporins
carbapenams
monobactams
All cephalosporins require renal dose adjustment except
ceftriaxone (rocephin)
3rd generation
These cephalosporins are active against G+ rods (some activity against gram -), name 3 drugs and generation
Cefadroxil (Duricef)
Cefazolin (Ancef, Kefzol)
Cephalexin (Keflex)
1st generation
available as an inhalation for this disease
CF
What is the spectrum coverage of carbapenems?
Very broad, gram pos, gram neg, anaerobes
Gram + only abx coverage, name the 4 drugs
Clindamycin
linezolid
Vancomycin
daptomycin
This cephalosporin has side effects of disulfiram reaction and hypoprothrombinemia
Cefotetan (cefotan)
second generation
This generation is highly active against gram negative rods and less active than 1st gen against gram pos.
3rd generation
What spectrum do monobactams cover?
ONLY gram negative, including P. aeruginosa. Requires addl agents for gram positive and anaerobic coverage.
What does carbapenem NOT cover
Does NOT cover P. aeruginosa, acinetobactor
this antibiotic works by inhibiting protein synthesis within transferase site of ribosome
ciprofloxacin
These two cephalosporins have pseudomonal coverage. Name antibiotic and generation
Ceftazidine (Fortaz)- 3rd generation
Cefepime (Maxipime)- 4th generation
This cephalosporin precipitates in neonatal bile and causes biliary sludging. Name drug and generation
Ceftriaxone
3rd generation
This monobactam has no cross reactivity with penicillins (a beta lactam)
Aztreonam (Azactam)
What significant drug drug interaction does this class have?
Valproic acid, can decrease levels
Cipro is well absorbed into tissues except
brain/CSF
Name the 2 antibiotics and generation that cover anaerobic
cefoxitin (Mefoxin) and cefotetan (Cefotan)
2nd generation
name these 6 cephalosporins from 3rd generation
cefdinir (omnicef)
Cefixime (Suprax)
Cefotaxime (Vantin)
Cefpodoxime (Vantin)
Ceftazidime (Fortaz)
Ceftriaxone (Rocephin)
Monobactams have a structure similar to ______
ceftazidime (Fortax)
3rd generation
Does not cover all gram negative and has significant resistance to
burkholderia cepacia
Stenatrophomonas maltophilia
major side effect of cipro
c diff