Neuropharmacology
What is Neuropharmacology?
study of drugs that alter processes controlled by the nervous system
What two neurotransmitters are effected in PD?
imbalance between dopamine and acetylcholine in the striatum
Haloperidol (Haldol) is classified as?
First Generation Antipsychotic (High Potency)
Fluoxetine is classified as?
Selective Serotonin Reuptake Inhibitors
What medications are given for short-term manic episodes in Bipolar?
lithium and valproate
Regulate the heart, Regulate the secretory glands & Regulate the smooth muscles
Drug Interactions of Levodopa?
First-generation antipsychotics, MAOI & Anticholinergic drugs
Clozapine is classified as?
Second Generation Atypical Antipsychotic Agents
Venlafaxine, Desvenlafaxine are classified as?
Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs)
What are the drugs that interact with Lithium?
•Diuretics
•Nonsteroidal anti-inflammatory drugs
•Anticholinergic drugs
Where is the neurotransmitter Epinephrine released from?
Adrenal Medulla
Bromocriptine is classified as?
Ergot Derivatives
What are signs and symptoms of an Anticholinergic responses related to medication therpay?
Dry mouth, blurred vision, photophobia, urinary hesitancy, constipation, tachycardia
Amitriptlyline is classified as?
Tricyclic Antidepressants (TCA)
What are the adverse effects of Benzodiazepines?
•CNS depression , Anterograde amnesia , Sleep driving, Respiratory depression, Abuse
What are the functions of Beta 1 receptors?
Increases:
•Heart rate
•Force of contraction
•Velocity of conduction in atrioventricular (AV) node
Donepezil, Rivastigmine and Galantamine are classified as?
Cholinesterase Inhibitors
What is the therapeutic use for clozapine?
Schizophrenia; Levodopa-induced psychosis
Isocarboxazid [Marplan] is classified as?
Monoamine Oxidase Inhibitors (MAOIs)
Zolpidem (Ambien)/ Eszopiclone (Lunesta) are classified as?
Benzodiazepine-like Drugs
What are the functions of Beta 2 Receptors?
Bronchial dilation
Relaxation of uterine muscle
Vasodilation
Glycogenolysis
Delay of preterm labor
Memantine is classified as?
NMDA receptor antagonists
Risperidone and Aripiprazole are classified as?
Second-Generation Antipsychotic Agents
What are the symptoms of Hypertensive crisis?
Severe headache, Tachycardia, Hypertension, Nausea and vomiting, Confusion, Profuse sweating, Stroke & Death
What is the main adverse effect of Barbiturates?
Respiratory depression