Pharm basics
The study of how drugs are moved through the body.
What is Pharmaokinetcs?
How is the medication going to be eliminated from the body?
What is excretion?
The time it takes for the drug concentration to be reduced by half (50%) in your body.
What is half-life?
Targeted
Empiric
Prophylactic
Maintenance
What are types of Therapy?
In place to catch and prevent an error which can cause harm to the patient.
What are the Rights of Medication Administration?
Med. going from the location of administration to the blood stream.
What is absorption?
Kidney dysfunction - leads to an ↑ in the duration and intensity of a medication response
(if the kidneys aren't working to excrete waste, the medication will stay in the body which leads to toxic levels)
What are impacting factors of Excretion?
TI
What is Therapeutic Index?
Treatment initiated before a definitive diagnosis is confirmed. (often a specific microorganism or condition is not yet identified)
What is Empiric Therapy?
Verify you are administrating it to the right patient with unique identifiers.
First and last name
date of birth
medical record number
What is the right CLIENT/PATIENT?
Oral- Longest absorption time.
SUBQ & IM -depends on blood perfusion at injection site (more Blood perfusion = rapid absorption)
IV - Quickest absorption time
What are factors impacting Absorption?
How is the medication going to be broken down?
What is Metabolism?
Level of medication in the body to produce the desired effect or outcome (usually measured by serum concentrations in the bloodstream)
What is the Therapeutic Index?
Treatment (especially in cancer) that selectively target specific molecules like proteins, inside or on the surface of cancer cells.
What is targeted therapy?
giving meds at the ordered time
What is the right TIME?
Transportation of the medication by bodily fluids to where it needs to go.
What is distribution?
Age
Medication type
first-pass
nutritional status
What is Metabolism?
The ability of a drug or other substance to be absorbed and used by the body.
What is Bioavailability?
A medication or treatment designed and used to prevent disease from reoccurring.
Specific vaccine travelling globally
What is Prophylactic therapy?
Verify the ordered dose
numbers and unit of measurement
double verification
What is the right Dose?
Permeability of the cell membrane
Plasma protein binding
circulation ↓circulation (ex Hemorrhage )= ↓ carrying capacity to take the medication to where it needs to be
What are impacting factors of Distribution?
Absorption
Distribution
Metabolism
Excretion
What is ADME?
Ingestion of the drug ORALLY
↓
Metabolized (usually by the liver or gut; can occur elsewhere like the lungs)
↓
Effect of the medication is REDUCED and only part of the drug reaches the systemic circulation
What is the first pass effect?
treatment administered after an initial treatment to help maintain a state of remission or to prevent a disease from recurring or progressing.
What is maintenance therapy?
What is right MEDICATION?